摘要
维持草酸盐稳态对于保护肾脏健康至关重要,目前对慢性肾脏病(CKD)中草酸盐稳态的了解仍然有限。本文重点关注CKD患者草酸盐稳态的复杂机制,探讨影响草酸盐积聚的关键因素,并讨论草酸盐在CKD进展和预后中的潜在作用,尤其是肠-肾轴在CKD草酸盐代谢中的重要性,及其治疗策略。
Maintaining oxalate homeostasis is crucial for preserving kidney health.Although the relationship between oxalate and kidney stone formation has been extensively studied,understanding of oxalate homeostasis in non-stone chronic kidney disease(CKD)is still limited.This review aims to analyze existing literature,focusing on the complex mechanisms of oxalate homeostasis in CKD,exploring key factors affecting oxalate accumulation,and discussing the potential role of oxalate in the progression and prognosis of CKD.The importance of the gut-kidney axis in CKD oxalate homeostasis,and outlines treatment strategies and possible approaches are also disccussed.
作者
侯金花(综述)
俞雨生(审校)
HOU Jinhua;YU Yusheng(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
2024年第3期264-268,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
江苏省肾脏病医学创新中心项目(CXZX202202)
东部战区总医院院内课题(2023LCYYXH012,22JCYYYB2)。
关键词
草酸盐
慢性肾脏病
草酸盐稳态
oxalate
chronic kidney disease
oxalate homeostasis
