摘要
目的:探讨坦索罗辛联合输尿管软镜钬激光碎石术对输尿管结石患者结石清除率及氧化应激的影响。方法:选取2022年6月~2023年6月期间于某院进行治疗的100例输尿管结石患者作为研究对象,采用随机数字表法分为对照组和观察组,每组50例。两组患者均给予输尿管软镜钬激光碎石术治疗,对照组患者术后给予止血、抗感染等常规治疗,观察组患者术后在对照组治疗基础上给予盐酸坦索罗辛缓释胶囊治疗。比较两组患者氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)及皮质醇(Cor)]、排石情况(结石排出时间、结石排净时间、排石疼痛评分和结石清除率)、临床疗效、复发率及不良反应发生情况。结果:治疗后,两组患者血清MDA、Cor水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者血清SOD水平均升高(P<0.05),且观察组高于对照组(P<0.05);观察组患者结石排出时间、结石排净时间均短于对照组(P<0.05),排石疼痛评分低于对照组(P<0.05),结石清除率高于对照组(P<0.05);观察组患者治疗总有效率(96.00%)高于对照组(80.00%,P<0.05);观察组患者经治疗后未出现复发,对照组7例(14.00%)患者出现复发,两组患者复发率比较具有统计学差异(χ^(2)=5.530,P=0.019)。两组患者不良反应发生率比较无统计学差异(χ^(2)=0.510,P=0.475)。结论:坦索罗辛联合输尿管软镜钬激光碎石术治疗输尿管结石患者临床疗效确切,可显著提高患者结石清除率,缓解排石疼痛,降低氧化应激反应,且复发风险较低。
Objective:To investigate the effects of tamsulosin combined with flexible ureteroscopic holmium laser lithotripsy on stone clearance rate and oxidative stress in patients with ureteral calculi.Methods:A total of 100 patients with ureteral calculi treated in a hospital from June 2022 to June 2023 were selected and assigned to the control group and observation group by random number table method,with 50 patients in each group.Both groups were treated with flexible ureteroscopic holmium laser lithotripsy,the control group was given conventional treatment such as hemostasis and anti-infection,and the observation group was given tamsulosin hydrochloride sustained-release capsules in addition to the treatment provided in the control group after surgery.The oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)and cortisol(Cor)],stone removal(stone removal time,stone-free time,pain score and stone clearance rate),clinical response,recurrence rate and adverse reactions were compared between the two groups.Results:After treatment,the serum MDA and Cor levels were decreased in both groups(P<0.05),and were lower in the observation group than those in the control group(P<0.05).The level of serum SOD was increased in both groups(P<0.05),and was higher in the observation group than that in the control group(P<0.05).The stone removal time and stone-free time in the observation group were earlier than those in the control group(P<0.05),the stone removal-associated pain score in the observation group was lower than that in the control group(P<0.05),and the stone clearance rate in the observation group was higher than that in the control group(P<0.05).The total response rate in the observation group(96.00%)was higher than that in the control group(80.00%,P<0.05).No patients in the observation group had recurrence after treatment,while 7 patients(14.00%)experienced recurrence in the control group.There was statistically significant difference in the recurrence rate between the two groups(χ^(2)=5.530,P=0.019).Th
作者
豆亚鹏
胡祥
DOU Ya-peng;HU Xiang(Department of Urology,YIMA Coal Group General Hospital,Yima 472300,China)
出处
《中国合理用药探索》
CAS
2024年第6期64-69,共6页
Chinese Journal of Rational Drug Use
基金
河南省医学科技攻关计划(联合共建)项目(LHGJ20190926)。
关键词
输尿管软镜钬激光碎石术
坦索罗辛
输尿管结石
结石清除率
氧化应激
flexible ureteroscopic holmium laser lithotripsy
tamsulosin
ureteral calculi
stone clearance rate
oxidative stress
