摘要
血栓性疾病是导致人类死亡的主要原因。沉默信息调节因子1(silent information regulator 1,SIRT1)调节炎症反应、氧化应激、血管生成、能量代谢以及内皮细胞功能等过程,在静脉血栓栓塞、缺血性脑卒中、心房颤动、动脉粥样硬化等血栓性疾病中发挥重要作用。本文就SIRT1的结构和生理功能,以及其参与血栓性疾病的机制和研究进展进行综述。
Thrombotic diseases are a major cause of human mortality.Silent information regulator 1(SIRT1)regulates processes such as inflammation,oxidative stress,vascular generation,energy metabolism,and endothelial cell function.It plays a crucial role in thrombotic diseases such as venous thromboembolism,ischemic stroke,atrial fibrillation,and atherosclerosis.This article provides a comprehensive review of the structure and physiological functions of SIRT1,as well as its involvement in the mechanisms and research progress of thrombotic diseases.
作者
吴彩娇
李小荣
霍瑞玲
应燕萍
WU Cai-jiao;LI Xiao-rong;HUO Rui-ling;YING Yan-ping(Department of Dermatovenereology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;不详)
出处
《广东医学》
CAS
2024年第5期647-651,共5页
Guangdong Medical Journal
基金
国家自然科学基金资助项目(81860032)
广西医科大学第一附属医院护理临床研究攀登计划项目基金资助项目(YYZS2020025)。
