摘要
肿瘤并不是单一生长的组织,其周围特异性的肿瘤微环境与其发展息息相关,肿瘤周围脑区是指肿瘤原发病灶周围邻近的大脑区域,在放射学上通常包括瘤周脑实质及瘤周水肿区域。充分认识并挖掘肿瘤及瘤周脑区的潜在放射学信息,将在肿瘤的科学研究及临床诊疗中获益。本文阐明了瘤周脑区的定义与形成机制,并对基于磁共振成像的各项技术,包括扩散成像、灌注成像、磁共振波谱成像、酰胺质子转移加权成像及影像组学,在颅内肿瘤周围脑区中的应用进展进行综述,旨在通过开展瘤周脑区的影像学研究继而为颅内肿瘤的鉴别诊断、基因分子分型、探寻术中切除范围、预测预后及监测疗效等方面提供新思路。
Tumors are not single-growing tissues,and the specific tumor microenvironment surrounding them is closely related to their development.Peritumor brain area refers to the adjacent brain area around the primary tumor lesion,and radiologically it usually includes peritumor brain parenchyma and peritumor edema area.Fully understanding and mining the potential radiological information of tumor and peritumoral brain area will benefit the scientific research and clinical diagnosis and treatment of tumor.In this article,we elucidate the definition and formation mechanism of the peritumor brain zone,and review the progress of magnetic resonance imaging-based techniques,including diffusion imaging,perfusion imaging,magnetic resonance spectroscopy,amide proton transfer-weighted imaging,and radiomics,in the application of the peritumor brain zone to intracranial tumors.The aim of this review is to provide new ideas for differential diagnosis,genomolecular typing,exploration of intraoperative resection range,prognosis prediction and monitoring of therapeutic efficacy of intracranial tumors.
作者
赵恩东
施禹彤
宋雪琳
娄诗云
杨超
ZHAO Endong;SHI Yutong;SONG Xuelin;LOU Shiyun;YANG Chao(Department of Radiology,the First Hospital of Dalian Medical University,Dalian 116000,China;Department of Radiology,the Second Hospital of Dalian Medical University,Dalian 116000,China;Department of Neurology,Dalian University Affiliated Xinhua Hospital,Dalian 116000,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第6期172-178,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:81771663)。
关键词
脑肿瘤
瘤周脑区
磁共振成像
影像组学
多模态
brain tumor
peritumor brain zone
magnetic resonance imaging
imaging omics
multimodality
