期刊文献+

无症状胶质瘤的差异性基因表达及其富集分析

Differential gene expression and enrichment analysis in asymptomatic gliomas
原文传递
导出
摘要 目的:分析有无症状世界卫生组织(WHO)2级脑胶质瘤的差异表达基因和相关富集通路,为胶质瘤的综合诊疗寻找新的靶点。方法:选取于2018年1月至2019年12月间在郑州大学第一附属医院神经外科接受手术治疗的27例WHO 2级脑胶质瘤患者[年龄(42.1±11.2)岁]进行本次研究。获取其临床随访资料和测序数据,将其分为无症状组(9例)和有症状组(18例)。通过R语言软件对比分析两组患者基因表达的差异。通过Metascape网站进行富集分析寻找相关富集通路。结果:在27例WHO 2级胶质瘤患者中,共筛选出127个差异表达基因,其中52上调基因,75个下调基因,并且在"急性炎性反应"、"血液循环"、"硫化合物结合"和"神经活性配体-受体相互作用"等通路中富集。结论:无症状WHO 2级胶质瘤具有特异性的基因表达差异并存在相关富集通路。 Objective To find a new target for the comprehensive diagnosis and treatment of gliomas,we analyzed the differentially expressed genes and related enrichment pathways of asymptomatic world health organization(WHO)grade 2 gliomas.Methods In total,27 patients aged(42.1±11.2)years old with WHO grade 2 glioma who received surgical treatment in Department of Neurosurgery of the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2019 were selected for this study.The clinical follow-up data and sequencing data were obtained and divided into asymptomatic group(9 cases)and symptomatic group(18 cases).The difference in gene expression between the two groups was analyzed by R language software.The Metascape website enrichment analysis was done to find the relevant enrichment pathways.Results In 27 WHO grade 2 glioma patients,127 differentially expressed genes were screened,including 52 up-regulated genes and 75 down-regulated genes,which were enriched in biological pathways such as acute inflammatory response,blood circulation,sulfur compound binding,and neuroactive ligand receptor interaction.Conclusion Asymptomatic WHO grade 2 gliomas exhibit specific gene expression differences and related enrichment pathways.
作者 冯亚文 毛冲冲 耿俊杰 邱锴 赵海彪 刘献志 Feng Yawen;Mao Chongchong;Geng Junjie;Qiu Kai;Zhao Haibiao;Liu Xianzhi(Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处 《中华实验外科杂志》 CAS 2024年第5期1055-1057,共3页 Chinese Journal of Experimental Surgery
关键词 神经胶质瘤 低级别 差异表达基因 富集分析 Glioma Low-grade Differentially expressed genes Enrichment analysis
  • 相关文献

参考文献3

二级参考文献24

  • 1鲍民,周健,栾国明.脑功能区病变继发性癫的外科治疗(附41例分析)[J].中国微侵袭神经外科杂志,2008,13(11):483-485. 被引量:7
  • 2刘宗惠,赵全军,李士月,田增民,康桂泉,冯海莉.多处软膜下横纤维切断术治疗顽固性功能区癫痫的实验及临床应用[J].中华神经外科杂志,1994,10(1):38-41. 被引量:28
  • 3张营.初治恶性胶质瘤术后放疗患者预后影响因素分析[D].太原:山西医科大学,2010. 被引量:1
  • 4Piotrowski AF, Blakeley J. Clinical Management of Seizures in Patients with Low-Grade Gliorna[ J]. Semin Radiat Oncol , 2015, 25 (3) :219-224. 被引量:1
  • 5Ruda R, Soffietti R. What is New in the Management of Epilepsy in Gliomas? [J]. Curr Treat Options Neurol , 2015, 17 (6): 351. DOI: 10. 1007/s11940-015-0351-8. 被引量:1
  • 6Rheims S, Ducray F, Ryvlin P. Choosing the tumoral epilepsy surgery candidate [ J ]. Epilepsia, 2013, 54 (9) :91-96. 被引量:1
  • 7Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome[J]. Neurology, 2009, 72(3) :217-223. DOI: 10. 1212/ 01. wnl. 0000334365. 22854. d3. 被引量:1
  • 8Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumors of the central nervous system [ J ]. Acta Neuropathol, 2007, 114 ( 2 ) : 97-109. 被引量:1
  • 9Forst DA, Nahed BV, Loeffler JS, et al. Low-grade gliomas [ J ]. Oncologist, 2014, 19 (4): 403413. DOI: 10. 1634/ theoncologist. 2013-0345. 被引量:1
  • 10Englot DJ, Berger MS, Barbaro NM, et al. Predictors of seizure freedom after resection of supratentorial low-grade gliomas. A review [J].J Neurosurg, 2011, 115 ( 2 ) : 240-244. DOI: 10. 3171/2011.3. jns1153. 被引量:1

共引文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部