摘要
目的观察子宫内膜癌(EC)患者代谢综合征发生情况,并分析其临床特征及预后情况。方法回顾性分析2016年1月至2017年11月在上海交通大学医学院附属上海儿童医学中心海南医院妇产科住院接受手术治疗的297例EC患者的临床资料,根据患者代谢综合征发生情况将其中合并代谢综合征的84例患者作为实验组,不合并代谢综合征的213例患者作为对照组。所有患者均完成5年随访,统计患者无进展生存率及总生存率,分析EC合并代谢综合征患者的临床特征及预后情况。结果实验组年龄≥55岁、绝经、临床分期为Ⅱ~Ⅳ期、有高血糖、有高血脂、有高血压、有淋巴结转移患者占比高于对照组,差异具有统计学意义(P<0.05);Logistic回归分析结果显示,年龄≥55岁、绝经、临床分期Ⅱ~Ⅳ期、有高血糖、有高血脂、有高血压、有淋巴结转移是EC患者合并代谢综合征的危险因素(OR>1,P<0.05);实验组无进展生存率及总生存率均低于对照组,差异具有统计学意义(P<0.05)。结论相较于无代谢综合征的EC患者,EC合并代谢综合征的患者预后较差,无进展生存率及总生存率较低。
Objective To observe the occurrence of metabolic syndrome in patients with endometrial cancer(EC),and to analyze its clinical characteristics and prognosis condition.Methods Retrospective analysis was used to collect the clinical data of 297 EC patients who underwent surgical treatment in the Department of Obstetrics and Gynecology of Affliated to Shanghai Jiao Tong University School of Medicine Shanghai Children's Medicine Center,Hainan Branch from January 2016 to November 2017.According to the occurrence of metabolic syndrome,84 patients with metabolic syndrome were divided into experimental group and 213 patients without metabolic syndrome were divided into control group.All patients completed a 5-year follow-up,patients'progression free survival rate and overall survival rate were recorded,and the clinical characteristics and prognosis condition of EC patients with metabolic syndrome were analyzed.Results The experimental group had a higher proportion of patients aged≥55 years,menopause,clinical stage Ⅱ-Ⅳ,with hyperglycemia,hyperlipidemia,hypertension,and lymph node metastasis compared to the control group,the difference was statistically significant(P<0.05).The results of Logistic regression analysis showed that age≥55 years,menopause,clinical stage Ⅱ-Ⅳ,hyperglycemia,hyperlipidemia,hypertension,and lymph node metastasis were risk factors for metabolic syndrome in EC patients(OR>1,P<0.05);the progression free survival rate and overall survival rate of the experimental group were lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusions Compared to EC patients without metabolic syndrome,EC patients with metabolic syndrome have a poorer prognosis,lower progression free survival rates and overall survival rates.
作者
符玉蕾
何涓
王艳
吉文倩
FU Yulei;HE Juan;WANG Yan;JI Wenqian(Department of Emergency,Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Children's Medicine Center,Hainan Branch,Sanya 572000,Hainan,China;Department of Obstetrics,Affiliatedto Shanghai Jiao Tong University School of Medicine Shanghai Children's Medicine Center,Hainan Branch,Sanya 572000,Hainan,China)
出处
《中国性科学》
2024年第6期66-69,共4页
Chinese Journal of Human Sexuality
基金
海南省自然科学基金项目(814382)。
关键词
子宫内膜癌
代谢综合征
临床特征
预后
体重指数
血脂
血糖
血压
Endometrial cancer
Metabolie syndrome
Clinical characteristics
Prognosis
Body mass index
Blood lipids
Blood glucose
Blood pressure
