摘要
目的:探讨医护人员血脂异常与高尿酸血症风险的关系,为医护人员健康管理及疾病防控提供依据。方法:选取2018—2022年惠州市第三人民医院344名医护人员作为研究对象,根据2018年体检血脂结果,分为血脂异常组(n=116)和血脂正常组(n=228)。于2019—2022年体检时随访,随访间隔时间1年。随访期间研究对象发生高尿酸血症或4次随访结束时尚未发生高尿酸血症,则随访结束。使用Cox比例风险回归模型分析血脂异常与高尿酸血症发病风险之间的关联。模型1为单因素Cox回归分析,模型2调整了年龄、性别和身高。结果:研究对象共随访810人年,平均随访时间2.36年,261人发生高尿酸血症,相对危险度为1.35,发病密度为155.6/1000人年。Cox回归分析结果表明血脂异常组高尿酸血症发病风险较高,2个模型中血脂异常组的HR(95%CI)分别为1.632(1.270,2.097)和1.721(1.319,2.245),均P<0.05。结论:血脂异常是医护人员发生高尿酸血症的危险因素。
Objective:To investigate the relationship between dyslipidemia and the risk of hyperuricaemia in medical staff,and to provide a basis for health management and disease prevention and control in medical staff.Methods:344 medical staff from Huizhou Third People's Hospital were selected as study subjects from 2018 to 2022 and divided into the dyslipidemia group(n=116)and the normal lipid group(n=228)according to the lipid results of the 2018 physical examination.Follow-up at the time of the 2018-2022 physical examination,with a follow-up interval of 1 year.Follow-up was completed if the study subject developed hyperuricaemia during the follow-up period or had not developed hyperuricaemia at the end of the 4 follow-up visits.Cox proportional hazard regression model were used to analyse the association between dyslipidaemia and the risk of developing hyperuricaemia.Model 1 was a one-way Cox regression analysis,and model 2 adjusted for age,sex,and height.Results:The study subjects were followed for a total of 810 person-years,with a mean follow-up time of 2.36 years,and 261 developed hyperuricaemia,with a relative risk of 1.35,and an incidence density of 155.6/1,000 person-years.The results of the Cox regression analysis indicated that the risk of developing hyperuricaemia was higher in the dyslipidaemic group,and the HR(95%CI)for the dyslipidaemic group in the 2 models were 1.632(1.270,2.097)and 1.721(1.319,2.245),both P<0.05.Conclusion:Dyslipidemia is a risk factor for the development of hyperuricaemia in medical staff.
作者
尹璇
张建军
YIN Xuan;ZHANG Jianjun(Department of Public Health and Preventive Medicine,Shantou University Medical College,Shantou 515041,China;Department of Medicine,Huizhou Third People's Hospital,Huizhou 516002,China)
出处
《汕头大学医学院学报》
2024年第2期81-84,共4页
Journal of Shantou University Medical College
