摘要
We need to talk about red blood cells.Eukaryotic cells are defined as cells containing distinct nuclei and other membranous organelles.However,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.
基金
A.T.A.was supported by an EHA Research Grant award granted by the European Hematology Association(RG202212-03039)
A.D.was supported by funds by the National Heart,Lung,and Blood Institute(R21HL150032,R01HL146442,R01HL149714,R01HL161004)
S.L.S and A.D.were supported by the National Institutes of Health(NIH R01-HL148151).
