摘要
目的:探究肺癌化疗患者血清TBNK淋巴细胞亚群水平变化,并分析其与预后的相关性。方法:分析2020年1月至2023年6月就诊于北京京煤集团总医院的92例肺癌化疗患者,行标准方案化疗,检测首次化疗前、化疗1、3个周期后TBNK淋巴细胞亚群水平,化疗结束后3个月评价预后,分为缓解组(63例)、未缓解组(29例),分析TBNK淋巴细胞亚群水平与预后的相关性。结果:Ⅲ期组化疗1、3个周期后CD3^(+)、CD3^(+)CD4^(+)、CD3^(-)CD19^(+)低于Ⅳ期组,CD3^(+)CD8^(+)、CD3^(-)CD16^(+)CD56^(+)高于Ⅳ期组(P<0.05);缓解组化疗1、3个周期后CD3^(+)、CD3^(+)CD4^(+)、CD3^(-)CD19^(+)低于未缓解组,CD3^(+)CD8^(+)、CD3^(-)CD16^(+)CD56^(+)高于未缓解组(P<0.05);肺癌化疗患者分期、预后与CD3^(+)、CD3^(+)CD4^(+)、CD3^(-)CD19^(+)呈正相关,与CD3^(+)CD8^(+)、CD3^(-)CD16^(+)CD56^(+)呈负相关(P<0.05);化疗3个周期后TBNK淋巴细胞亚群联合预测肺癌化疗患者预后的AUC最大,为0.907(P<0.05)。结论:肺癌化疗患者外周血TBNK淋巴细胞亚群变化与免疫功能状态及预后有关,监测相关指标水平可预测肺癌化疗患者预后。
Objective:To explore changes in the serum TBNK lymphocyte subset levels in patients with lung cancer undergoing chemother-apy and analyze their correlation with prognosis.Methods:Ninety-two patients undergoing standard regimen lung cancer chemotherapy who attended Beijing Jingmei Group General Hospital from January 2020 to June 2023 were selected.The level of TBNK lymphocyte subpop-ulations was detected before the first chemotherapy and after one and three cycles of chemotherapy.Their prognosis was evaluated 3 months after the end of chemotherapy and assigned into the remission group(63 cases)and the non-remission group(29 cases).The correl-^(+)ation between the levels of TBNK lymphocyte subsets and prognosis was analyzed.Results:The CD3^(+),CD3^(+)CD4^(+),and CD3^(-)CD19 levels in the^(+)stageⅢgroup were lower than those in the stageⅣgroup after one and three cycles of chemotherapy,while the CD3^(+)CD8 and^(+)^(+)CD3^(-)CD16^(+)CD56 levels were higher than those in the stageⅣgroup(P<0.05).The CD3^(+),CD3^(+)CD4^(+),and CD3-CD19 levels in the remission^(+)group were lower than those in the non-remission group after one and three cycles of chemotherapy,while the CD3^(+)CD8 and^(+)CD3-CD16^(+)CD56 levels were higher than those in the non-remission group(P<0.05).The staging and prognosis of lung cancer patients un-dergoing chemotherapy positively correlated with CD3^(+),CD3^(+)CD4^(+),and CD3^(-)CD19^(+),and negatively correlated with CD3^(+)CD8 and^(+)CD3^(-)CD16^(+)CD56(P<0.05).The area under the curve(AUC)of the TBNK lymphocyte subsets combined to predict the prognosis of lung can-cer patients after three cycles of chemotherapy was the highest,reaching 0.907(P<0.05).The TBNK lymphocyte subsets have a good risk warning effect on the prognosis of patients with lung cancer undergoing chemotherapy.Conclusions:Changes in peripheral blood TBNK lymphocyte subsets in patients with lung cancer undergoing chemotherapy were associated with immune function status and prognosis.Monitoring the levels of the relevant indi
作者
吕丽媛
杨冬明
倪超
钱方
王鹏飞
Liyuan Lv;Dongming Yang;Chao Ni;Fang Qian;Pengfei Wang(Department of Clinical Laboratory,Beijing Jingmei Group General Hospital,Beijing 102300,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2024年第6期302-307,共6页
Chinese Journal of Clinical Oncology
关键词
肺癌
TBNK淋巴细胞亚群
化疗
ROC曲线
相关性
危险度
lung cancer
TBNK lymphocyte subsets
chemotherapy
receiver operating characteristic(ROC)curve
relevance
risk degree
