摘要
缺氧缺血性脑损伤(Hypoxic-ischemia brain inury,HIBI)是导致新生儿后期病残及死亡的重要原因。新生儿在发育阶段对脑损伤的适应性在脑功能重组中发挥着重要作用,HIBI后大脑可通过神经元再生、突触重塑、胶质细胞增生等机制来进行修复与重建。了解HIBI的病理损伤机制、影像手段及大脑可塑性,有助于把握治疗的时间窗,并为新生儿HIBI损伤治疗带来新的机遇及前景。
Hypoxic-ischemic brain injury(HIBI)is an important cause of morbidity and mortality in late neonatal life.Neonatal adaptation to brain damage during development plays an important role in the reorganization of post-HIBI brain function.After HIBI,some mechanisms are involved in the brain repairs and rebuilding,such as nerve cell regeneration,synaptic remodeling,and glial cell proliferation.Understanding pathological injury mechanisms,imaging methods,and brain plasticity of HIBI contributes to grasping the time window of treatment and brings new opportunities and prospects for the treatment of neonatal HIBI.
作者
张琴
郑阳
ZHANG Qin;ZHENG Yang(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中国临床医学影像杂志》
CAS
CSCD
北大核心
2024年第6期439-443,共5页
Journal of China Clinic Medical Imaging
基金
国家自然科学基金青年基金项目(81801658)。
关键词
脑损伤
婴儿
新生
磁共振成像
Brain Injuries
Infant,Newborn
Magnetic Resonance Imaging
