摘要
抑郁症是精神科自杀率最高的疾病,目前治疗抑郁症的药物在长期治疗时会伴随许多副作用。抑郁症的病因及发病机制复杂,多项研究发现植物中广泛分布的黄酮类化合物对抑郁症有显著的改善作用。近年来大量证据表明肠道菌群的改变与抑郁症的发生发展密切相关,黄酮类化合物可以影响肠道菌群的组成及代谢产物,进而通过微生物-肠-脑轴影响人体的情绪和行为。本文综述了近年来国内外关于肠道菌群与抑郁症之间相互作用的研究成果,探讨了基于肠道菌群的黄酮类化合物通过调节炎症因子、神经递质、短链脂肪酸等从而改善抑郁症的潜在机制,为后续探索抑郁症发病机制与预防、改善抑郁症提供研究思路。
Depression is a psychiatric disorder with the highest suicide rate,and current medication for depression often comes with numerous side effects during long-term treatment.The causes and pathogenesis of depression are complex.Many studies have suggested that various flavonoids,which widely distributed in plants,are significantly effective in improving depression.Additionally,a substantial body of recent research has demonstrated a close relationship between changes in the gut microbiota and the development of depression.Flavonoids can alter the composition and metabolites of the gut microbiota,thereby affecting human emotion and behavior through the microbiota-gut-brain axis.This article provides a review of research findings on the interaction between the gut microbiota and depression.It also discusses the potential mechanism through which flavonoids,via the gut microbiota,could ameliorate depression by regulating inflammatory factors,neurotransmitters,short-chain fatty acids,and other related factors,hoping to provide ideas for follow-up research to explore the pathogenesis,prevention and improvement of depression.
作者
郝丹丹
申丹
付复华
苏东林
李绮丽
张馨懿
陈嘉序
李涛
李高阳
HAO Dandan;SHEN Dan;FU Fuhua;SU Donglin;LI Qili;ZHANG Xinyi;CHEN Jiaxu;LI Tao;LI Gaoyang(Longping Branch,College of Biology,Hunan University,Changsha 410125,China;Hunan Agricultural Products Processing Institute,Changsha 410125,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2024年第12期368-377,共10页
Food Science
基金
湖南省农业科技创新资金项目(2023CX23,2022CX02)
长沙市自然科学基金项目(kq2202334)
湖南康麓生物医药科技创新创业团队。
