摘要
钆吡醇是成人和2岁及以上儿科患者在采用核磁共振成像(MRI)探测和观察中枢神经系统(大脑、脊柱和相关组织)和身体(头颈、胸部、腹部、骨盆和肌肉骨骼系统)是否具有异常血管特性病变时使用的一种造影剂。钆吡醇是一种新型的大环钆基造影剂(GBCA),本文现从钆吡醇的分子结构、作用机制、药效学、药代动力学、临床研究和安全性等方面进行综述,以介绍该药的研究现状和已有成果。
Gadopiclenol was used in adults and pediatric patients 2 years of age and older during magnetic resonance imaging(MRI)to detect and view lesions of the central nervous system(brain,spine,and associated tissues)and body(head and neck,chest,abdomen,pelvis,and musculoskeletal system)with abnormal vascular properties.Gadopiclenol is a new type of macrocyclic gadolinium-based contrast agent(GBCA).In this article,the molecular structure,principle of action,pharmacodynamics,pharmacokinetics,clinical studies,safety and other aspects of Gadopiclenol were reviewed,in order to introduce the current research status and existing achievements of Gadopiclenol.
作者
郑璐
杨婷
陈超阳
魏然
张玄龄
邓靖中
周颖
ZHENG Lu;YANG Ting;CHEN Chao-yang;WEI Ran;ZHANG Xuan-ling;DENG Jing-zhong;ZHOU Ying(Department of Pharmacy,Peking University First Hospital,Bejing 100034,China;Department of Pharmacy,Peking University First Hospital Taiyuan Hospital,Taiyuan 030000,Shanxi Province,China;Drug Clinical Trial Institution,Peking University First Hospital,Bejing 100034,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2024年第11期1661-1664,共4页
The Chinese Journal of Clinical Pharmacology
关键词
钆吡醇
核磁共振成像
造影剂
大环钆基造影剂
Gadopiclenol
magnetic resonanceimaging
radiological diagnostic
gadolinium-based contrast agent
