摘要
目的对槐耳颗粒在原发性肝癌治疗中所起作用的系统评价进行再评价,为临床决策提供切实可靠的参考依据。方法检索槐耳颗粒治疗原发性肝癌系统评价的文献,运用系统综述和meta分析优先报告的条目(PRISMA)声明、改良的系统评价方法学质量评价工具(AMSTAR)2量表和推荐分级评估、制订与评价(GRADE)系统工具进行评估。结果最终纳入4篇文献,总样本量8040例。在报告质量的27个条目中完全符合的比例分别为66.67%、62.96%、66.67%和70.37%。AMSTAR2量表显示4篇文献质量均为极低。GRADE系统工具评价显示中等质量证据9个,低等质量证据8个,极低质量证据18个。结论目前槐耳颗粒治疗原发性肝癌的系统评价在报告完整性、方法学质量、结局指标的证据强度上均有不同程度的缺陷,仍需更多高质量研究验证以提供更可靠的循证医学证据来指导临床。
Objective To conduct the reevaluation on the systematic evaluation of the role of Huaier Granules in the treatment of primary liver cancer to provide the practical and reliable reference basis for clinical decision.Methods The literatures on the systematic evaluation of Huaier granules in the treatment of primary liver cancer was retrieved.The evaluation was performed by the preferred reporting items for systematic reviews and meta-analyses(PRISMA)statement,a measure tool to assess systematic reviews(AMSTAR)2 scale and the grading of recommendations assessment,development and evaluation(GRADE)system tool.Results Finally,4 literatures with a total sample size of 8040 cases were included.In 27 items with the reported quality,the proportions of complete agreement were 66.67%,62.96%,66.67%and 70.37%,respectively.AMSTAR2 scale showed that the quality of the four articles was very low.The GRADE system tool evaluation showed that there were 9 medium quality evidences,8 low quality evidences and 18 extremely low quality evidences.Conclusion At present,the systematic evaluation of Huaier Granules in the treatment of primary liver cancer has different degrees of defects in the integrity of the report,methodological quality,and evidence strength of outcome indicators,which still needs more high-quality studies to provide more reliable evidence-based medical evidence to guide clinical practice.
作者
李锴
吴传新
王娜
孙航
LI Kai;WU Chuanxin;WANG Na;SUN Hang(Department of Hepatobiliary;Institue of Viral Hepatitis,Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《重庆医学》
CAS
2024年第12期1864-1869,1877,共7页
Chongqing medicine
基金
重庆市科卫联合医学科研项目(2022MSXM048)。
