摘要
变应性鼻炎(allergic rhinitis,AR)是以上气道高反应为主要特征的鼻黏膜慢性炎症,涉及多种免疫细胞及炎性介质,目前以药物、免疫和手术治疗为主。研究发现,间充质干细胞具有免疫调节能力,在AR的治疗中具有临床应用前景。本文将从间充质干细胞的作用机制、其对AR关键细胞的免疫调节作用及目前应用面临的挑战展开综述,以期为AR的治疗提供新的思路。
Allergic rhinitis is a chronic nasal mucosal inflammation characterized by upper airway hyperresponsiveness,involving a variety of immune cells and inflammatory mediators.Drugs,immunotherapy,and surgical operation are the principal treatments at present.The study found that mesenchymal stem cells have the ability of immune regulation and have a promising clinical application in the treatment of allergic rhinitis.In this review,the action mechanism of mesenchymal stem cells,the immunomodulatory effect of mesenchymal stem cells on the key cells of allergic rhinitis,and the challenges of clinical application are reviewed,to provide new directions for the treatment of allergic rhinitis.
作者
李文瑾
王艳杰
程冯丽
祁雪萍
安云芳
赵长青
LI Wenjin;WANG Yanjie;CHENG Fengli;QI Xueping;AN Yunfang;ZHAO Changqing(Second School of Clinical Medicine,Shanxi Medical University,Taiyuan,030001,China;Department of Otorhinolaryngology Head Neck Surgery,the Second Hospital,Shanxi Medical University,Key Research Laboratory of Airway Neuroimmunology)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2024年第5期442-447,452,共7页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家自然科学基金资助(No:81870707、82171119、82171120、82201263)。
关键词
变应性鼻炎
间充质干细胞
免疫调节
allergic rhinitis
mesenchymal stem cell
immune regulation
