摘要
目的了解那曲市HBV母婴阻断实施现况,发现母婴阻断工作存在的问题,降低母婴传播的发生。方法从那曲市东、中、西三个地区单纯随机抽取6家医院,调查2020年1月1日至12月31日期间住院分娩的孕产妇产前HBV标志物筛查率、HBsAg阳性率、HBsAg阳性产妇的新生儿乙型肝炎疫苗第一针和乙型肝炎免疫球蛋白(HBIG)联合及时接种率和未及时接种的原因、母婴阻断后免疫后血清学检测(post-vaccination serological test,PVST)开展情况。结果6家医院共调查孕产妇4132名,产前HBV标志物筛查率为100.00%(4132/4132),其中HBsAg阳性孕产妇阳性率为10.36%(428/4132)。在428名HBsAg阳性孕产妇的新生儿中93.46%(400/428)的新生儿及时进行了HepB1和HBIG联合接种,28名未及时接种,主要原因为出生低体重(早产)(19名)和新生儿黄疸(6名)。共有100名婴儿符合PVST检测条件,只有21.00%(21/100)进行了检测,HBsAg均为阴性,但有7名婴儿抗-HBs阴性,其中仅2人进行了1剂次补种。79名婴儿未进行PVST的主要原因为家长不知晓(82.28%,65/79)。结论那曲市住院孕产妇HBsAg筛查率达到100%的要求,低出生体重和新生儿黄疸是未及时进行乙型肝炎疫苗第1针和HBIG联合接种的主要原因,家长不知道需要检测是未进行PVST检测的主要原因。
Objective:To understand the implementation status of prevention of mother-to-child transmission of HBV in Naqu City,so as to identify problems in the prevention work,and reduce the incidence of mother-to-child transmission.Methods:A survey was conducted in 6 hospitals randomly selected from the eastern,central and western regions of Naqu City from January 1 to December 31,2020.The rate of HBV screening for pregnant women before delivery,the HBsAg positive rate,the timely vaccination rate of the 1st dose of hepatitis B vaccine(HepB1)combined with hepatitis B immunoglobulin(HBIG)for newborns of HBsAg positive mothers,the reasons for delayed vaccination,the status of post-vaccination serological test(PVST)were investigated.Results:A total of 4132 pregnant women were investigated in 6 hospitals,and the screening rate of HBV markers for pregnant women before delivery was 100.00%(4132/4132),among whom the HBsAg positive rate was 10.36%(428/4132).Of the 428 newborns delivered by HBsAg positive mothers,93.46%(400/428)were timely vaccinated with HepB1 combined with HBIG,while 28 were delayed,mainly due to low birth weight(premature birth)(19 cases)and neonatal jaundice(6 cases).There were 100 infants who met the conditions for PVST,but only 21.00%(21/100)were tested,and all HBsAg results were negative.However,7 infants were anti-HBs negative,and only 2 of them were given a supplemental dose of HepB vaccine.The main reason for not performing PVST in 79 infants was that their parents did not know about it,accounting for 82.28%(65/79).Conclusions:The HBsAg screening rate of hospitalized pregnant women in Naqu City reaches 100%.Low birth weight and neonatal jaundice are the main reasons for delayed vaccination of HepB1 combined with HBIG.Lack of awareness among parents is the main reason for not performing PVST.
作者
云丹尖措
张丽杰
Yundan Jiancuo;Zhang Lijie(Naqu Prefecture Center for Disease Control and Prevention,Naqu 852000,China;Chinese Field Epidemiology Training Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)
出处
《国际流行病学传染病学杂志》
CAS
2024年第2期116-119,共4页
International Journal of Epidemiology and Infectious Disease
基金
中国现场流行病学培训项目(131031001000200011)。
关键词
肝炎
乙型
HBSAG
母婴传播阻断
现况调查
Hepatitis B
HBsAg
Prevention of mother-to-child transmission
Investigation
