摘要
目的探讨糖尿病患者在吡格列酮给药基础上联用二甲双胍的效果及药学作用。方法选取2022年6月—2023年6月山东省莱阳市中医医院药剂科收治的100例糖尿病患者为研究对象,采用随机数表法分为两组,各50例,对照组单用吡格列酮,观察组同时联用二甲双胍,对比两组血糖指标、胰岛素指标、血脂指标、炎性反应指标及不良反应发生率。结果治疗后,观察组各项血糖指标水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组空腹胰岛素、餐后2 h胰岛素水平均高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组甘油三酯、总胆固醇、低密度脂蛋白胆固醇均低于对照组,高密度脂蛋白胆固醇高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组各项炎性因子均低于对照组,差异有统计学意义(P均<0.05)。两组不良事件发生率比较,差异无统计学意义(P>0.05)。结论糖尿病患者在吡格列酮给药基础上联用二甲双胍药物,可降低血糖水平,改善胰岛素及血脂状况,减轻炎性反应程度,且具一定安全性。
Objective To investigate the effect and pharmaceutical effect of pioglitazone combined with metformin in diabetic patients.Methods A total of 100 diabetic patients admitted to the Pharmacy Department of laiyang Hospital of Traditional Chinese Medicine of Shandong Province from June 2022 to June 2023 were selected as the study ob-jects.The patients were divided into two groups by random number table method,with 50 cases in each group.The control group was treated with pioglitazone alone,while the observation group was treated with metformin at the same time.The blood glucose index,insulin index,lipid index,inflammatory response index and the incidence of adverse re-action of the two groups were compared.Results After treatment,the levels of blood glucose indexes in the observa-tion group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Af-ter treatment,the fasting insulin and 2-hour postprandial insulin levels in the observation group were higher than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,triacylglyc-erol,total cholesterol and low density lipoprotein cholesterol in observation group were lower than those in control group,and high density lipoprotein cholesterol was higher than those in control group,and the differences were statisti-cally significant(all P<0.05).After treatment,all inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).There was no significant differ-ence in the incidence of adverse events between the two groups(P>0.05).Conclusion In diabetic patients,piogli-tazone combined with metformin can reduce blood sugar level,improve insulin and lipid status,reduce inflammatory reaction degree,and has a certain safety.
作者
张红
姜俊良
姚军华
ZHANG Hong;JIANG Juniang;YAO Junhua(Department of Pharmacy,Laiyang Hospital of Traditional Chinese Medicine,Laiyang,Shandong Province,265200)
出处
《糖尿病新世界》
2024年第7期71-74,共4页
Diabetes New World Magazine
关键词
糖尿病
吡格列酮
二甲双胍
药学作用
Diabetes mellitus
Pioglitazone
Metformin
Pharmaceutical effect