摘要
【目的】观察自拟类风湿二方(由黄芪桂枝五物汤加鸡血藤、宽筋藤、广东海风藤、木瓜等中药组成)联合巴瑞替尼和甲氨蝶呤治疗寒湿痹阻型类风湿性关节炎(RA)的临床疗效。【方法】将60例寒湿痹阻型RA患者随机分为观察组和对照组,每组各30例。对照组给予巴瑞替尼+甲氨蝶呤治疗,观察组在对照组的基础上联合自拟类风湿二方治疗,疗程为8周。观察2组患者治疗前后中医证候积分、疼痛程度视觉模拟量表(VAS)评分以及红细胞沉降率(ESR)和血清C反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸肽抗体(anti-CCP)等相关实验室指标的变化情况,并评价2组患者的临床疗效。【结果】(1)疗效方面:治疗8周后,观察组的总有效率为93.33%(28/30),对照组为70.00%(21/30),组间比较(χ^(2)检验),观察组的疗效明显优于对照组(P<0.05)。(2)中医证候积分方面:治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.05或P<0.01),且观察组的降低幅度明显优于对照组(P<0.01)。(3)疼痛程度方面:治疗后,2组患者的疼痛程度VAS评分均较治疗前明显降低(P<0.01),且观察组的降低幅度明显优于对照组(P<0.01)。(4)相关实验室指标方面:治疗后,2组患者的ESR和血清CRP、RF、anti-CCP水平均较治疗前明显降低(P<0.05),且观察组的降低幅度均明显优于对照组(P<0.05)。【结论】自拟类风湿二方内服联合巴瑞替尼和甲氨蝶呤治疗寒湿痹阻型RA疗效确切,可有效缓解患者的临床症状和体征,改善患者的相关实验室指标,其疗效优于单纯西药巴瑞替尼和甲氨蝶呤治疗。
Objective To observe the clinical efficacy of self-made Rheumatoid No.2 Formula(derived from Huangqi Guizhi Wuwu Decoction with Spatholobi Caulis,Tinosporae sinensis Caulis,Guangdong Piperis Kadsurae Caulis,Chaenomelis Fructus,etc.added)combined with Barrettinib and Methotrexate for the treatment of rheumatoid arthritis(RA)of cold-damp obstruction type.Methods Sixty patients with RA of cold-damp obstruction type were randomly divided into an observation group and a control group,with 30 cases in each group.The control group was treated with Baritinib and Methotrexate orally,and the observation group was treated with self-made Rheumatoid No.2 Formula orally on the basis of treatment for the control group.The course of treatment covered 8 weeks.The changes of traditional Chinese medicine(TCM)syndrome score,pain visual analogue scale(VAS)score,erythrocyte sedimentation rate(ESR),serum C-reactive protein(CRP),rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(anti-CCP)and other related laboratory indicators in the two groups before and after treatment were observed.After treatment,the clinical efficacy of the two groups was evaluated.Results(1)After 8 weeks of treatment,the total effective rate of the observation group was 93.33%(28/30),and that of the control group was 70.00%(21/30).The intergroup comparison(tested by chi-square test)showed that the efficacy of the observation group was significantly superior to that of the control group(P<0.05).(2)After treatment,the scores of TCM syndromes in the two groups were significantly lower than those before treatment(P<0.05 or P<0.01),and the decrease in the observation group was significantly superior to that in the control group(P<0.01).(3)After treatment,the VAS scores of pain in the two groups were significantly lower than those before treatment(P<0.01),and the decrease in the observation group was significantly superior to that in the control group(P<0.01).(4)After treatment,the levels of related laboratory indicators of ESR and serum CRP,RF and anti-CC
作者
熊甚
薛秋倩
郑宝林
XIONG Shen;XUE Qiu-Qian;ZHENG Bao-Lin(The Eighth Clinical Medical School of Guangzhou University of Chinese Medicine,Foshan 528000 Guangdong,China;Foshan Hospital of Traditional Chinese Medicine,Foshan 528000 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2024年第6期1438-1443,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局科研项目(编号:20220292)
佛山市“十四五”中医药重点专科项目(编号:ZDZKJS35)。
关键词
类风湿性关节炎
寒湿痹阻
类风湿二方
黄芪桂枝五物汤
巴瑞替尼
甲氨蝶呤
rheumatoid arthritis
cold-damp obstruction
Rheumatoid No.2 Formula
Huangqi Guizhi Wuwu Decoction
Barretinib
Methotrexate
