摘要
目的探讨超声血流参数、血清治疗前刺激性甲状腺球蛋白(ps-Tg)/促甲状腺激素(TSH)联合检测对甲状腺癌患儿术后复发的评估价值。方法选取42例甲状腺癌患儿,均行外科手术治疗,依据术后复发情况,分为复发组和未复发组。比较两组患儿的血流分级、超声血流参数[阻力指数(RI)、搏动指数(PI)、收缩期峰值流速/舒张末期流速比值(S/D)]、血清学指标[甲状腺球蛋白(Tg)、TSH、ps-Tg、甲状腺球蛋白抗体(TgAb)和ps-Tg/TSH]。以病理检查结果为金标准,评估超声血流参数、ps-Tg/TSH单独及联合检测对甲状腺癌患儿术后复发的评估价值,一致性分析采用Kappa检验。结果42例甲状腺癌术后患儿,复发24例,未复发18例,复发组与未复发组患儿血流分级情况比较,差异无统计学意义(P﹥0.05)。复发组患儿RI、PI、S/D、ps-Tg和ps-Tg/TSH均明显高于未复发组,差异均有统计学意义(P﹤0.01);两组患儿TgAb、TSH水平比较,差异均无统计学意义(P﹥0.05)。超声血流参数、ps-Tg/TSH联合检测诊断甲状腺癌患儿术后复发的灵敏度为91.67%,特异度为88.89%,准确度为90.48%,其与病理检查结果的一致性较高(Kappa=0.806),联合检测对甲状腺癌患儿术后复发的评估价值优于二者单独检测。结论超声血流参数、ps-Tg/TSH联合检测对甲状腺癌患儿术后复发有较高评估价值,其诊断灵敏度、特异度、准确度均高于二者单独检测。
Objective To investigate the evaluation value of ultrasound blood flow parameters,serum preablative stimulated thyroglobulin(ps-Tg)/thyroid stimulating hormone(TSH)combined detection for postoperative recurrence of thyroid cancer in children.Method A total of 42 children with thyroid cancer were selected,all of whom underwent surgical treatment.Based on postoperative recurrence,they were divided into recurrent group and non-recurrent group.The blood flow grading,ultrasound blood flow parameters[resistance index(RI),pulsatility index(PI),systolic peak velocity/diastolic end velocity(S/D)],serological indicators[thyroglobulin(Tg),TSH,ps-Tg,thyroglobulin antibody(TgAb),ps-Tg/TSH]were compared between two groups.Using pathological examination results as the gold standard,the evaluation value of ultrasound blood flow parameters,ps-Tg/TSH single and combined detection for postoperative recurrence in children with thyroid cancer were evaluated.Kappa test was used for consistency analysis.Result Among the 42 postoperative children with thyroid cancer,24 had recurrence and 18 had no recurrence.There was no statistically significant difference in blood flow grading between the recurrent group and the non-recurrent group(P>0.05).The RI,PI,S/D,ps-Tg,and ps-Tg/TSH of the recurrent group were significantly higher than those of the non-recurrent group,and the differences were statistically significant(P<0.01).There were no statistically significant differences in the levels of TgAb and TSH between the two groups(P>0.05).The sensitivity,specificity,and accuracy of ultrasound blood flow parameters,ps-Tg/TSH combined detection in diagnosing postoperative recurrence in children with thyroid cancer were 91.67%,88.89%,and 90.48%,respectively.The consistency between ultrasound blood flow parameters,ps-Tg/TSH combined dection in diagnosing postoperative recurrence in children with thyroid cancer and pathological examination was high(Kappa=0.806),and the combined detection had a better evaluation value for postoperative recurrence in ch
作者
张蕾
方华
黄柏清
ZHANG Lei;FANG Hua;HUANG Boqing(Department of Pediatrics,Xinyang Central Hospital,Xinyang 464000,He’nan,China)
出处
《癌症进展》
2024年第8期921-925,共5页
Oncology Progress
关键词
超声血流参数
治疗前刺激性甲状腺球蛋白
促甲状腺激素
甲状腺癌
术后复发
ultrasound blood flow parameter
preablative stimulated thyroglobulin
thyroid stimulating hormone
thyroid cancer
postoperative recurrence
