探究气道激素雾化吸入联合前列地尔治疗老年AECOPD合并PH患者疗效及对肺血管功能指标的影响

To explore the efficacy of airway hormone nebulization combined with alprostadil in the treatment of elderly patients with AECOPD combined with PH and the effects on pulmonary vascular function indexes

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摘要目的探究气道激素雾化吸入联合前列地尔治疗老年慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)患者的疗效及对肺血管功能指标的影响。方法采用随机数字表法对2020年3月-2022年8月收治的80例老年AECOPD合并PH患者进行分组,每组各40例,两组均采取常规治疗,对照组采取布地奈德联合沙丁胺醇气道雾化治疗,观察组在其基础上增加雾化吸入前列地尔治疗,对比两组临床疗效、治疗前后肺功能指标以及肺血管功能指标,同时观察不良反应。结果观察组与对照组相比,临床总有效率较高,差异有统计学意义(P<0.05)。观察组治疗后与对照组治疗后相比,肺功能指标中FEV1、FEV1/FVC值均较高,肺血管功能指标中Cpw值较高,TRP值较低,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论气道激素雾化吸入联合前列地尔治疗老年AECOPD合并PH患者的临床效果显著,患者的肺功能以及肺血管功能指标均得到了明显的改善,且治疗期间无明显不良反应,安全性较高。 Objective To explore the efficacy of airway hormone nebulization combined with alprostil in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary hypertension(PH)and its influence on pulmonary vascular function indexes.Method Eighty elderly patients with AECOPD combined with PH treated from March 2020 to August 2022 were divided into groups by random number table method,with 40 cases in each group.Both groups received conventional treatment,the control group received budesonide combined with salbutamol airway atomization therapy,and the observation group was additionally treated with atomized inhalation of alprostadil.The clinical efficacy,pulmonary function indexes and pulmonary vascular function indexes before and after treatment were compared between the two groups,and adverse reactions were observed.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Compared with the control group after treatment,FEV1 and FEV1/FVC values of pulmonary function indexes in the observation group were higher,Cpw values of pulmonary vascular function indexes were higher,and TRP values were lower,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Airway hormone nebulization combined with alprostadil in the treatment of elderly AECOPD patients with PH has significant clinical effects,and the pulmonary function and pulmonary vascular function indexes of patients have been significantly improved,and there are no obvious adverse reactions during treatment,and the safety is high.

作者杜杨袁峰蒋芳帆 Du Yang;Yuan Feng;Jiang Fangfan(Beijing Yanqing District Hospital Pneumology department,Beijing 102100,China)

机构地区北京市延庆区医院

出处《首都食品与医药》 2024年第11期70-72,共3页 Capital Food Medicine

关键词气道雾化吸入前列地尔老年慢性阻塞性肺疾病急性加重期疗效肺血管功能指标不良反应 airway atomization inhalation Alprostadil Chronic obstructive pulmonary disease in the elderly Acute exacerbation stage Curative effect Pulmonary vascular function index Adverse reaction

分类号 R563 [医药卫生—呼吸系统]