摘要
目的分析输尿管结石碎石术后运用盐酸坦索罗辛缓释胶囊、双石通淋胶囊联合辅助排石的效果及对炎症因子的影响。方法120例输尿管结石碎石术后患者,通过随机数字表法分为对照组和观察组,每组60例。对照组采取盐酸坦索罗辛缓释胶囊治疗,观察组采用盐酸坦索罗辛缓释胶囊+双石通淋胶囊治疗。比较两组临床疗效、用药不良反应发生率及治疗前后炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、疼痛感变化情况。结果与对照组相比,观察组治疗总有效率(95.00%VS 81.67%)更高(P<0.05)。治疗后,对照组和观察组CRP、IL-6、TNF-α均低于治疗前,且与对照组相比,观察组CRP(2.84±0.81 VS 5.36±1.21)mg/L、IL-6(97.79±0.33 VS 122.16±13.57)pg/ml、TNF-α(4.31±1.19 VS 6.44±1.31)μg/L均更低(P<0.05)。治疗后,对照组和观察组视觉模拟评分法(VAS)评分均低于治疗前,且与对照组相比,观察组VAS评分(1.86±0.24 VS 3.58±0.89)分更低(P<0.05)。与对照组相比,观察组用药不良反应发生率(6.67%VS 21.67%)更低(P<0.05)。结论对输尿管结石碎石术后患者采取盐酸坦索罗辛缓释胶囊、双石通淋胶囊联合治疗,可起到辅助排石作用,降低炎症相关因子表达水平,减轻术后疼痛感,且用药不良反应发生率较低,临床安全性、有效性较高,值得推荐。
Objective To analyze the effect of tamsulosin hydrochloride sustained-release capsules combined with Shuangshi Tonglin capsule in assisting with stone removal after ureteral lithotripsy and its influence on inflammatory factors.Methods 120 patients with ureteral lithotripsy were divided into a control group and an observation group by random number table method,with 60 cases in each group.The control group was treated with tamsulosin hydrochloride sustained-release capsule,and the observation group was treated with tamsulosin hydrochloride sustained-release capsule+Shuangshi Tonglin capsule.The clinical efficacy,incidence of adverse drug reactions,changes of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and pain sensation before and after treatment were compared between the two groups.Results Compared with the control group,the total effective rate of the observation group was higher(95.00%VS 81.67%)(P<0.05).After treatment,CRP,IL-6 and TNF-αin the control group and the observation group were lower than those before treatment;and compared with the control group,CRP(2.84±0.81 VS 5.36±1.21)mg/L,IL-6(97.79±0.33 VS 122.16±13.57)pg/ml and TNF-α(4.31±1.19 VS 6.44±1.31)μg/L were lower in the observation group(P<0.05).After treatment,the visual analogue scale(VAS)scores of both the control group and the observation group were lower than those before treatment;and compared with the control group,VAS scores of the observation group were lower(1.86±0.24 VS 3.58±0.89)points(P<0.05).Compared with the control group,the incidence of adverse drug reactions(6.67%VS 21.67%)in the observation group was lower(P<0.05).Conclusion The combination of tamsulosin hydrochloride sustained-release capsule and Shuangshi Tonglin capsule for patients after ureteral lithotripsy can play an auxiliary role in stone removal,reduce the level of expression of inflammation-related factors,and alleviate postoperative pain.Besides,the incidence of adverse drug reactions is low,and the clinic
作者
熊涛
XIONG Tao(Department of Urology,Zhongshan West District Hospital,Zhongshan 528400,China)
出处
《中国现代药物应用》
2024年第11期36-40,共5页
Chinese Journal of Modern Drug Application
关键词
输尿管结石
碎石术
盐酸坦索罗辛缓释胶囊
双石通淋胶囊
术后排石
炎症因子
Ureteral calculi
Lithotripsy
Tamsulosin hydrochloride sustained-release capsule
Shuangshi Tonglin capsule
Postoperative stone removal
Inflammatory factor
