摘要
口腔白斑(oral leukoplakia, OLK)指发生于口腔黏膜上不能被擦去、也不能以临床或组织病理学方法诊断为其他可定义的疾病的白色损害,是一种口腔黏膜癌前病变。现有治疗OLK的方法中,非手术治疗如药物治疗缺乏其防止OLK恶性转化和复发的确切证据;而手术治疗则存在适应证窄、术后口腔形态及功能受损等不足;光动力疗法(photodynamic therapy, PDT)是一种现代的非侵入性疗法,可用于治疗包括口腔白斑在内的各种肿瘤及非肿瘤病变,由于其良好的组织形态及功能保存潜能,现已成为治疗口腔白斑的一种新型且前景广阔的治疗选择。该文就PDT治疗口腔白斑应用的光敏剂、光源及其辅助治疗手段作一综述。
Oral leukoplakia(OLK)is defined as the white lesions that occur on the oral mucosa which cannot be erased and cannot be clinically or pathologically diagnosed as any other definable diseases.It is a precancerous lesion of the oral muco-sa.Existing treatments for OLK include non-surgical treatments and surgical treatments.However,promising evidence regard-ing the prevention of malignant transformation and recurrence of OLK by non-surgical treatments(such as pharmacotherapy)is needed.Meanwhile,surgical treatments have limited indications and postoperative oral morphology and function impair-ment.Photodynamic therapy(PDT)is a modern non-invasive therapy,which can be used to treat tumors and non-tumor lesions including oral leukoplakia,and has become a new and promising option for the treatment of oral leukoplakia due to its potential of preserving tissue morphology and function.In this paper,photosensitizers and lights of PDT and adjuvant treatment methods for PDT in the treatment of oral leukoplakia were reviewed.
作者
张若雁
王军
Zhang Ruoyan;Wang Jun(Second Clinical Medical College,Nanchang University,Nanchang 330006,China;Department of Stomatology,the Second Af filiated Hospital of Nanchang University,Nanchang 330006,China)
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2024年第3期420-425,共6页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
江西省自然科学基金资助项目(No.20171BAB205050)。
关键词
光动力疗法
口腔白斑
光敏剂
CO_(2)激光
梅花针
photodynamic therapy
oral leukoplakia
photosensitizer
CO_(2) laser
plum-blossom needle
