摘要
目的探讨基于冠状动脉CT血管成像(Coronary CT Angiography,CCTA)测量心外膜脂肪组织(Epicardial Adipose Tissue,EAT)体积及CT值参数对冠心病的应用价值。方法选取2021年1月—2023年6月的冠心病患者50例作为冠心病组,取同期在本院体检的健康者40例作为对照组。所有纳入者均临床资料完整,且CCTA图像齐全。利用syngo.via后处理工作站软件,获得EAT体积(cm^(3))及CT值(HU)数据。随后收集冠心病组和对照组的性别、年龄和低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)指标。计量资料组间比较采用独立样本t检验,计数资料组间比较采用χ^(2)检验,以P<0.05为差异有统计学意义。应用MedCalc统计绘图软件绘制ROC曲线,并通过AUC进行各指标对冠心病诊断效能的比较。结果冠心病组和对照组在性别、年龄、EAT体积、EAT的平均CT值、LDL-C方面差异有统计学意义(χ^(2)/t分别为9.723、3.958、4.302、-3.09和3.727,均P<0.05)。性别、年龄、EAT体积、EAT平均CT值和LDL-C诊断冠心病的灵敏度分别为68%、66%、62%、62%和50%,特异度分别为65%、75%、82.5%、68.5%和100%。其中EAT指标EAT体积和EAT平均CT值诊断冠心病的阈值分别为>122.95cm^(3)和≤-86HU,对应的AUC分别为0.738和0.637。结论性别、年龄、EAT体积、EAT平均CT值和LDL-C均有助于诊断冠心病,其中基于CCTA测量EAT参数(如EAT体积、EAT平均CT值)作为新兴技术获取指标,对提高冠状动脉粥样硬化性心脏病的诊断能效具有一定价值。
Objective To explore the application value of EAT volume and CT value parameters measured by CCTA in coronary heart disease.Methods Fifty patients with CHD from January 2021 to June 2023 were selected as the CHD group,and 40 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.All patients had complete clinical data and CCTA images.The volume(cm^(3))and CT value(HU)of EAT were obtained by syngo.via post-processing workstation software.Subsequently,the gender,age and LDL-C indexes of CHD group and control group were collected.Independent sample t test was used to compare the measurement data between groups,andχ^(2)test was used to compare the count data between groups.P<0.05 was considered statistically significant.ROC curve was drawn by MedCalc statistical drawing software,and AUC was used to compare the diagnostic efficacy of each index for coronary heart disease.Results There were significant differences in gender,age,volume of EAT,average CT value of EAT and LDL-C between CHD group and control group(χ^(2)/t=9.723,3.958,4.302,-3.09 and 3.727,respectively,all P<0.05).The sensitivity of gender,age,EAT volume,EAT average CT value and LDL-C in the diagnosis of CHD were 68%,66%,62%,62%and 50%,respectively,and the specificity were 65%,75%,82.5%,68.5%and 100%,respectively.The thresholds of EAT volume and EAT average CT value for the diagnosis of CHD were>122.95cm^(3) and≤-86HU,respectively,and the corresponding AUC were 0.738 and 0.637,respectively.Conclusion Gender,age,EAT volume,EAT average CT value and LDL-C are helpful for the diagnosis of coronary heart disease.The EAT parameters(such as EAT volume and EAT average CT value)measured by CCTA as emerging technology acquisition indicators have certain value in improving the diagnostic efficiency of coronary atherosclerotic heart disease.
作者
潘智荣
李思欣
王梓延
叶汝娴
Pan Zhirong;Li Sixin;Wang Ziyan;Ye Ruxian(Department of Imaging,Qingyuan Hospital Affiliated to Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan 511518,China;Department of Nuclear Medicine,Qingyuan Hospital Affiliated to Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan 511518,China;Department of Physical Examination,Qingyuan Hospital Affiliated to Guangzhou Medical University(Qingyuan People's Hospital),Qingyuan 511518,China)
出处
《现代仪器与医疗》
CAS
2024年第2期7-11,共5页
Modern Instruments & Medical Treatment
基金
清远市科技计划自筹经费项目(清科[2024]1号-12、清科[2023]2号-2)
广州医科大学2023年度本科教学质量与教学改革工程建设项目(2023JXGG030)
2023—2024年度广州医科大学第六临床学院大学生科技创新项目(广医六院[2022]6号)。
关键词
冠状动脉病变
心脏病
CT血管造影术
病例对照研究
回顾性研究
ICoronary artery disease
Heart diseases
Computed tomography angiography
Case-control studies
Retrospective studies
