摘要
目的探讨儿童精神分裂症(COS)康复监测过程中感觉门控脑电波P50的变异性。方法回顾性选取2017年2月至2020年9月嘉兴市第一医院、上海市精神卫生中心和上海市长宁区精神卫生中心收治的59例COS患儿为COS组,同期就读于上海市东安路小学和襄阳南路小学的38名健康学生为对照组,均行脑电波P50检测[采用条件刺激(S_(1))和测试刺激(S_(2))范式]。随访COS患儿治疗3年后疗效,比较两组儿童治疗前P50指标[包括S_(1)-P50潜伏期和波幅、S_(2)-P50潜伏期和波幅以及S_(2)-P50波幅与S_(1)-P50波幅比值(S_(2)/S_(1))],分析COS患儿中央区(Cz)脑区P50指标与阳性和阴性精神症状评定量表(PANSS)评分的相关性,比较COS患儿治疗前及治疗1、2、3年后Cz脑区P50指标。结果COS患儿利培酮治疗3年后总有效率为71.2%。与对照组比较,COS组额区、顶区和Cz脑区S_(2)-P50波幅以及S_(2)/S_(1)均较高(均P<0.05);两组儿童3个脑区S_(1)-P50潜伏期和波幅、S_(2)-P50潜伏期比较,差异均无统计学意义(均P>0.05)。COS患儿Cz脑区5个P50指标与PANSS激活性因子评分均呈正相关(均P<0.05),与PANSS总分及其他分量表评分均未见相关性(均P>0.05)。COS患儿治疗前后多个时点Cz脑区S_(1)-P50潜伏期和波幅、S_(2)-P50潜伏期和波幅以及S_(2)/S_(1)比较,差异均无统计学意义(均P>0.05)。结论COS患儿存在P50缺陷,3年跟踪随访过程中P50变异可能是本组COS的生物学状态标志。
Objective To investigate sensory gating P50 in patients with childhood-onset schizophrenia(COS)during rehabilitation.Methods Fifty-nine COS patients treated in Jiaxing First Hospital,Shanghai Mental Health Center and Shanghai Changning District Mental Health Center from February 2017 to September 2020 were enrolled,and 38 healthy children were selected as controls.P50 was detected using the stimulation sequence S_(1) and S_(2) paradigms in all subjects.The effects of COS children were followed up after 3 years of treatment,and P50 indexes were compared between the two groups before treatment,including S_(1)-P50 latency and amplitude,S_(2)-P50 latency and amplitude,and the ratio of S_(2)-P50 to S_(1)-P50 amplitude(S_(2)/S_(1)).The correlation between P50 indexex of central zero(Cz)and positive and negative syndrome scale(PANSS)score in COS children was analyzed,and the P50 indexes of Cz before and 1,2 and 3 years after treatment in COS children were compared.Results The effective rate in COS patients was 71.2%after 3 years of risperidone treatment.Compared with the control group,S_(2)-P50 amplitude and S_(2)/S_(1) in frontal zero,parietal zero and Cz brain regions were higher in COS group(all P<0.05).There were no significant differences in S_(1)-P50 latency and amplitude,S_(2)-P50 latency in three brain regions between two groups (all P>0.05). The five P50 indexes in Cz brain region of COS children were positively correlated with PANSS activating factor scores (all P<0.05), but no correlation was found with PANSS total score and other subscale scores (all P>0.05). There were no significant differences in S_(1)- P50 latency and amplitude, S_(2)- P50 latency and amplitude, and S_(2)/S_(1) in Cz brain region at multiple time points before and after COS treatment (all P>0.05). Conclusion COS patients have P50 defects. P50 variation during 3-year follow-up may be the biological status marker of COS in this group.
作者
刘超
梁超
陶峰
顾超
胡进
顾爱明
陈兴时
陈冲
杨道良
LIU Chao;LIANG Chao;TAO Feng;GU Chao;HU Jin;GU Aiming;CHEN Xingshi;CHEN Chong;YANG Daoliang(Department of Psychology,Jiaxing First Hospital,Jiaxing 314000,China;不详)
出处
《浙江医学》
CAS
2024年第11期1142-1146,共5页
Zhejiang Medical Journal
基金
浙江省教育厅高校直属附属医院抗疫专项(Y202043570)
上海市长宁区科委科研项目(CNKW2020Z05)。
关键词
精神分裂症
儿童
感觉门控
随访
Schizophrenia
Children
Feeling door control
Follow up
