摘要
癫痫是最常见的神经系统疾病之一,认知障碍是癫痫常见的并发症,严重影响患者的生活质量,而其发病机制较复杂且目前未研究清楚。突触可塑性是癫痫及认知障碍发生的重要机制,近年来越来越多的研究证实,细胞黏附分子Nectin-1在突触可塑性中发挥重要的作用,且在癫痫模型大鼠的海马组织异常表达,并通过影响突触可塑性引起癫痫的发生、认知功能障碍。现就细胞黏附分子Nectin-1在癫痫认知障碍的可能机制进行综述,以期寻求潜在的干预措施。
Epilepsy is one of the most common nervous system diseases.Cognitive impairment is a common complication of epilepsy and seriously affects the quality of life of patients.However,the pathogenesis of cognitive impairment in epilepsy is complex and has not been clearly studied yet.Synaptic plasticity is an important mechanism underlying the occurrence of epilepsy and cognitive impairment.In recent years,more and more studies have confirmed that cell adhesion molecule nectin-1 plays an essential role in synaptic plasticity.Nectin-1 is abnormally expressed in the hippocampus of rat models of epilepsy,and causes epilepsy and cognitive impairment by affecting the synaptic plasticity.This review summarizes the possible roles of cell adhesion molecule nectin-1 in cognitive impairment in epilepsy with a view to exploring potential intervention measures.
作者
吴金秀
丁奕宸
冯占辉
于云莉
Wu Jin-xiu;Ding Yi-chen;Feng Zhan-hui;Yu Yun-li(School of Clinical Medicine,Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Neurology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China)
出处
《中国现代医学杂志》
CAS
2024年第12期40-45,共6页
China Journal of Modern Medicine
基金
贵州省卫生健康委科学技术基金(No:gzwkj2021-29)
贵州医科大学附属医院博士科研启动基金(No:gyfybsky-2021-32)
贵州医科大学附属医院国家自然科学基金地区基金培育计划(No:gyfynsfc-2021-50)。
