摘要
目的探讨延边地区原发性肝癌(PHC)患者甲胎蛋白(AFP)水平的影响因素。方法收集2016年至2022年延边医院480例PHC患者的临床资料进行回顾性分析。临床资料包括一般情况、饮酒、血清蛋白水平、肝硬化、门静脉癌栓、肿瘤大小以及数目和乙型肝炎病毒(HBV)的感染情况以及AFP水平,采用单因素和logistic回归分析方法分析PHC患者AFP的影响因素。结果单因素分析结果显示,PHC患者AFP水平与性别、民族、肝硬化、门静脉癌栓、肿瘤数目以及HBV标志物有关,差异有统计学意义(P<0.05);与年龄、四项肝功能指标、肿瘤大小以及饮酒无关,差异无统计学意义(P>0.05)。Logistic回归分析显示,门静脉癌栓(β=1.837,OR=6.280,95%CI=3.061~12.883)、HBV标志物阳性(β=2.049,OR=0.341,95%CI=3.976~15.160)、肿瘤数目多发(β=0.541,OR=1.717,95%CI=1.087~2.713)是AFP水平的独立危险因素(P<0.05)。结论PHC患者AFP水平与性别、民族、肝硬化、门静脉癌栓、肿瘤数目和HBV标志物的感染等因素有相关性,门静脉癌栓、HBV标志物阳性和肿瘤数目多发是PHC的独立危险因素。
Objective To investigate the influencing factors of alpha-fetoprotein(AFP)level in patients with primary hepatic carcinoma(PHC)in Yanbian area.Methods The clinical data of 480 patients with PHC in Yanbian Hospital from 2016 to 2022 was retrospectively analyzed.Clinical data included general condition,alcohol consumption,serum protein level,liver cirrhosis,portal vein cancer thrombus,tumor size and number,hepatitis B virus(HBV)infection and AFP level.Univariate and logistic regression analysis were used to analyze the influencing factors of AFP in PHC patients.Results The results of single factor analysis showed that the level of AFP in patients with PHC was related to gender,nationality,cirrhosis,portal vein cancer thrombus,tumor number and HBV markers,with statistical significances(P<0.05).The level of AFP in patients with PHC was not related to age,four liver function indexes,tumor size and alcohol consumption,the differences were not significant(P>0.05).Logistic regression analysis showed that portal vein cancer thrombus(β=1.837,OR=6.280,95%CI=3.061-12.883),HBV marker positive(β=2.049,OR=0.341,95%CI=3.976-15.160),multiple tumor(β=0.541,OR=1.717,95%CI=1.087-2.713)were independent risk factors for AFP levels(P<0.05).Conclusion AFP levels in patients with PHC were correlated with gender,ethnicity,cirrhosis,portal vein cancer thrombus,tumor number and HBV marker infection.Positive portal vein cancer thrombus,HBV marker positive and multiple tumor were independent risk factors for PHC.
作者
李飒
俞星
臧龙正
LI Sa;YU Xing;ZANG Longzheng(Medical College,Yanbian University,Jilin Province,Yanji133002,China)
出处
《中国当代医药》
CAS
2024年第17期112-115,共4页
China Modern Medicine
基金
吉林省卫生健康科技能力提升项目(2021JC064)。
关键词
原发性肝癌
甲胎蛋白
影响因素
延边地区
Primary hepatic carcinoma
Alpha-fetoprotein
Influencing factor
Yanbian area
