摘要
本研究为了探讨恶性黑色素瘤的临床诊断及鉴别诊断要点,通过组织病理学检查和免疫组织化学染色方法对两例犬恶性黑色素瘤进行诊断。组织病理学检查发现瘤细胞排列紊乱,细胞主要呈梭形和上皮样两种细胞形态,可见瘤巨细胞、核分裂相,肿瘤细胞胞质中可见色素颗粒,细胞异型性明显,核仁较大,有丝分裂活跃,属于恶性黑色素瘤典型的组织学表现。免疫组织化学染色发现六种肿瘤标记物结果显示为CK(-)、Vimentin(+)、S-100(+)、CD34(-)、SMA-α(-)、KI-67(+)。通过组织病理学检查和免疫组化染色结果可以诊断为恶性黑色素瘤。
In order to evaluate the clinical diagnosis and differential diagnosis of malignant melanoma,two cases of malignant melanoma in dogs were diagnosed by histopathology and immunohistochemical staining.Histopathological examination showed cancer disorder,major fusiform cells and epithelioid two cell morphology,visible tumor giant cells,mitotic figures,tumor cells visible pigment granules in the cytoplasm,cell atypia,nucleoli larger,mitotic activity,belong to malignant melanoma typical histological features.Six kinds of tumor markers by immunohistochemistry showed CK(-),Vimentin(+),S-100(+),CD34(-),SMA-α(-),KI-67(+).In conclusion,observation by histopathology and immunohistochemistry results can be diagnosed as malignant melanoma.
作者
旷冬梅
李小敏
冯强
杨彩霞
张光洁
KUANG Dongmei;LI Xiaomin;FENG Qiang;YANG Caixia;ZHANG Guangjie(Hengyang Agricultural Comprehensive Administrative Law Enforcement Detachment,Hengyang Hunan 421001,China;China Hengyang Animal Husbandry and Aquatic Products Af fairs Center)
出处
《畜牧兽医杂志》
2024年第3期140-142,共3页
Journal of Animal Science and Veterinary Medicine
关键词
黑色素瘤
免疫组织化学
病理诊断
Melanoma
immunohistochemistry
pathological diagnosis
