摘要
目的分析在复发性肝癌治疗中采用射频消融与肝动脉化疗栓塞术改善肝癌肿瘤标志物水平的效果。方法前瞻性随机选取2020年1月—2023年1月福建省漳州市医院收治的60例复发性肝癌患者为研究对象,按随机数表法将其分为观察组和对照组,各30例。对照组患者采用肝动脉化疗栓塞术治疗,观察组采用射频消融治疗。比较两组复发性肝癌患者治疗总有效率、治疗期间不良反应发生情况以及治疗前后肝癌肿瘤标志物(异常凝血酶原、糖类抗原199、甲胎蛋白)水平改善情况。结果两组术前肝癌肿瘤标志物水平对比,差异无统计学意义(P均>0.05);术后两组异常凝血酶原、糖类抗原199、甲胎蛋白平均明显改善,且观察组优于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P=0.037)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论射频消融治疗复发性肝癌的效果优于肝动脉化疗栓塞术,更有利于控制患者病情,改善肿瘤标志物的表达。
Objective To analyze the effect of radiofrequency ablation and hepatic arterial chemoembolization in the treatment of recurrent liver cancer on the level of tumor markers.Methods 60 patients with recurrent liver cancer treated in Zhangzhou Hospital of Fujian Province from January 2020 to January 2023 were prospective randomly selected as the study objects and were divided into the observation group and control group by random number table method,with 30 cases in each group.The control group was treated with hepatic arterial chemoembolization,and the observation group was treated with radiofrequency ablation.The total effective rate,the occurrence of adverse reactions during treatment and the improvement of tumor markers(abnormal prothrombin,carbohydrate antigen 199,alpha-fetoprotein)before and after treatment were compared between the two groups.Results There were no statistically significant differences in tumor markers in the two groups before surgery(P>0.05);the levels of abnormal prothrombin,carbohydrate antigen 199 and alpha-fetoprotein in the two groups were improved after surgery,and those in observation group were better than in control group,the differences were statistically significant(all P<0.05).The total effective rate of the observation group was 93.33%,higher than the control group's 73.33%,the difference was statistically significant(χ^(2)=4.320,P=0.037).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The efficacy of radiofrequency ablation in the treatment of recurrent liver cancer is better than that of hepatic arterial chemoembolization,which is more conducive to the control of patients'disease and improve the expression of tumor markers.
作者
刘明强
LIU Mingqiang(Zhangzhou Hospital of Fujian Province,Zhangzhou,Fujian Province,363000 China)
出处
《中外医疗》
2024年第12期21-24,共4页
China & Foreign Medical Treatment
关键词
射频消融
肿瘤标志物
肝动脉化疗栓塞术
不良反应
复发性肝癌
效果
Radio frequency ablation
Tumor markers
Hepatic arterial chemoembolization
Adverse reactions
Recurrent liver cancer
Effect
