摘要
目的 分析丹栀逍遥散合甘麦大枣汤联合疏肝调神针法对偏头痛临床疗效及对血清肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)和降钙素基因相关肽(Calcitonin gene related peptide, CGRP)水平的影响。方法 选择齐齐哈尔市中医医院2020年3月—2022年3月收治的126例偏头痛患者,使用随机数字表法分别纳入联合组(n=63)、对照组(n=63)。两组均给予盐酸氟桂利嗪片口服,并给予疏肝调神针法针灸治疗,联合组加用丹栀逍遥散合甘麦大枣汤,持续1个月。对比两组治疗前后头痛症状、生活质量变化,并比较两组治疗前后脑血流动力学、血清指标变化,分析两组临床疗效。结果 头痛症状方面,两组治疗1个月后头痛发作频率、每月无头痛天数、发作时疼痛视觉模拟评分(Visual Analog Scale, VAS)、单次头痛持续时间均较治疗前下降;联合组治疗1个月后头痛发作频率、每月无头痛天数、发作时VAS评分、单次头痛持续时间均低于对照组,差异有统计学意义(P<0.05)。生活质量方面,两组治疗1个月后偏头痛生活品质问卷(Migraine-SpecificQualityLifeQuestionnaire, MSQ)量表各维度评分及总分均较治疗前下降;联合组治疗1个月后MSQ量表各维度评分及总分均低于对照组,差异有统计学意义(P<0.05)。脑血流动力学方面,两组治疗1个月后双侧大脑中动脉(middle cerebral artery, MCA)、基底动脉(Basilar artery, BA)、大脑后动脉(Posterior cerebral artery, PCA)、大脑前动脉(Anterior cerebral artery, ACA)血流速度均较治疗前下降;联合组治疗1个月后MCA、BA、PCA、ACA血流速度均低于对照组,差异有统计学意义(P<0.05)。血清指标方面,两组治疗1个月后血清TNF-α、ICAM-1、CGRP均较治疗前下降;联合组治疗1个月后血清TNF-α、ICAM-1、CGRP均低于对照组,差异有统计学意义(P<0.05)。联合组治疗1个月后总有效率为90.4
Objective To analyze the clinical effect of Danzhi Xiaoyao Powder(丹栀逍遥散)combined with Ganmai Dazao Decoction(甘麦大枣汤)combined with soothing liver and regulating the spirit acupuncture on migraine and its influence on the levels of serum tumor necrosis factor-α(TNF-α),intercellular adhesion molecule-1(ICAM-1)and calcitonin gene-related peptide(CGRP).Methods One hundred and twenty-six migraine patients admitted to Qiqihar Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were randomly divided into the combined group(63 cases)and the control group(63 cases).Both groups were given flunarizine hydrochloride tablets orally and were treated with soothing liver and regulating the spirit acupuncture.The combined group was treated with Danzhi Xiaoyao Powder and Ganmai Dazao Decoction for one month.The changes of headache symptoms,quality of life,cerebral hemodynamics and serum indexes before and after treatment were compared between the two groups,and the clinical efficacy of the two groups was analyzed.Results In terms of headache symp-toms,the frequency of headache attack,the number of headache-free days per month,the visual analogue scale(VAS)of pain at attack and the duration of a single headache in the two groups decreased after one month of treatment.After one month of com-bined treatment,the frequency of headache attack,the number of headache-free days per month,VAS score at attack and the du-ration of a single headache in the combined group were all lower than those in the control group with statistical significance(P<0.05).In terms of quality of life,the scores and total scores of migraine-specific quality life questionnaire(MSQ)scale in both groups decreased after one month of treatment.After one month of combined treatment,the scores and total scores of MSQ scale in the combined group were lower than those in the control group,and the difference was statistically significant(P<0.05).In terms of cerebral hemodynamics,the blood flow velocity of bilateral middle cerebral art
作者
唐宇
程为平
周佳
田叶
郎笑菲
TANG Yu;CHENG Weiping;ZHOU Jia;TIAN Ye;LANG Xiaofei(Qiqihar Hospital of Traditional Chinese Medicine,Qiqihar 161000,Heilongjiang,China;First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150036,Heilongjiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第6期113-116,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局龙江医学流派传承工作室建设项目(LPGZS2012-14)。
关键词
丹栀逍遥散
甘麦大枣汤
疏肝调神针法
偏头痛
临床疗效
Danzhi Xiaoyao Powder(丹栀逍遥散)
Ganmai Dazao Decoction(甘麦大枣汤)
soothing liver and regulating the spirit acupuncture
migraine
clinical efficacy
