摘要
目的:观察芪丹颗粒联合盐酸二甲双胍对脾虚痰瘀型2型糖尿病患者胰岛素抵抗、血清核因子-κB(NF-κB)及肿瘤坏死因子-α(TNF-α)的影响。方法:选取100例脾虚痰瘀型2型糖尿病患者,按随机数字表法分为治疗组及对照组各50例。对照组给予盐酸二甲双胍治疗,治疗组给予二甲双胍联合芪丹颗粒治疗。2组均治疗8周。比较2组临床疗效,比较2组治疗前后中医证候积分、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、腹围(AC)、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HLD-C)]、血清NF-κB、TNF-α水平的变化。结果:治疗后,对照组与治疗组临床疗效总有效率分别为80.00%、94.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降(P<0.05),治疗组中医证候积分低于对照组(P<0.05)。治疗后,2组HOMA-IR、BMI、AC指标值均较治疗前下降(P<0.05),治疗组HOMA-IR、BMI、AC指标值均低于对照组(P<0.05)。治疗后,2组TC、TG、LDL-C水平均较治疗前下降(P<0.05),HLD-C水平均较治疗前上升(P<0.05);治疗组TC、TG、LDL-C水平均低于对照组,差异有统计学意义(P<0.05),HDL-C水平与对照组比较,差异无统计学意义(P>0.05)。治疗后,2组血清NF-κB、TNF-α水平均较治疗前下降,治疗组血清NF-κB、TNF-α治疗前后比较,差异有统计学意义(P<0.05);治疗组血清NF-κB、TNF-α水平均低于对照组(P<0.05)。结论:芪丹颗粒联合盐酸二甲双胍能改善脾虚痰瘀型2型糖尿病患者胰岛素抵抗,下调血清NF-κB、TNF-α水平,改善脂肪组织的炎症反应,缓解临床症状。
Objective:To observe the effect of Qidan Granules combined with Metformin Hydrochloride on insulin resistance,serum nuclear factor-kB(NF-kB)and tumor necrosis factor-α(TNF-α)in patients with type 2 diabetes mellitus(T2DM)of spleen deficiency and obstruction of phlegm and blood stasis type.Methods:A total of 100 patients with T2DM of spleen deficiency and obstruction of phlegm and blood stasis type were selected and divided into the treatment group and the control group according to the random number table method,with 50 cases in each group.The control group was given Metformin Hydrochloride,and the treatment group was given Metformin Hydrochloride combined with Qidan Granules.After 8 weeks of treatment,the clinical effects in the two groups were compared,and the changes of traditional Chinese medicine(TCM)syndrome scores,Homeostatic Model Assessment of Insulin Resistance(HOMA-IR),body mass index(BMl),abdominal circumference(AC),blood lipids[total cholesterol(TC),triglyceride(TG),loW density lipoprotein(LDL-C),high density lipoprotein(HLD-C)),serum NF-kB and TNF-&were compared before and after treatment between the two groups.Results:After treatment,the total effective rate was 80.00%in the control group and 94.00%in the treatment group,the difference being significant(P<0.05).After treatment,the TCM scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the treatment group was lower than that in the control group(P<0.05).After treatment,the levels of HOMAIR,BMl,and AC in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of HOMA-IR,BMl,and AC in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of TC,TG,and LDL-C in the two groups were decreased when compared with those before treatment(P<0.05),and the HLD-C levels was increased when compared with those before treatment(P<0.05);the levels of TC,TG,and LDL-C in the treatment group were lower than those in th
作者
雷自红
陈冬妮
郭叙喜
张越
叶仁群
LEI Zihong;CHEN Dongni;GUO Xuxi;ZHANG Yue;YE Renqun(The Seventh Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518133,China;Department of Endocrinology,Shenzhen Bao'an Traditional Chinese Medicine Hospital,Shenzhen Guangdong 518133,China)
出处
《新中医》
CAS
2024年第9期76-81,共6页
New Chinese Medicine
基金
深圳市宝安区科技计划项目(2022JD221)
芪三丹颗粒(2022KJCX-YYZJ-4)。
关键词
2型糖尿病
脾虚痰瘀型
芪丹颗粒
盐酸二甲双胍
胰岛素抵抗
Type 2 diabetes mellitus
Syndrome of spleen deficiency and obstruction of phlegm and blood stasis
Qidan Granules
Metformin Hydrochloride
Insulin resistance
