摘要
目的:评价血府逐瘀汤联合常规西医治疗对急性加重期慢性阻塞性肺病(COPD)患者的肺功能指标和炎症指标的影响。方法:本研究于2020年10月~2023年6月,研究对象为本院呼吸科82例急性加重期COPD患者,采用随机数字表法分成两组。对照组(41例)仅接受常规西医治疗,观察组(41例)接受常规西医联合使用血府逐瘀汤治疗。比较两组临床疗效、中医证候积分、肺功能指标[用力肺活量(FVC)、一秒用力呼气容积(FEV1)、肺一氧化碳弥散量(DLCO)]、炎症指标[白细胞计数(WBC)、血清白介素6(IL-6)、白三烯B4(LT-B4)、超敏C反应蛋白(hs-CRP)]。结果:观察组治疗总有效率为90.24%(37/41)显著高于对照组73.17%(30/41),差异显著(P<0.05);治疗前,两组在所有观察指标上差异不显著(P>0.05),治疗后,观察组中医证候积分显著低于对照组(P<0.05);FVC、FEV1高于对照组,差异显著(P<0.05),两组的DLCO比较无统计学差异(P>0.05);观察组的炎症因子水平显著低于对照组(P<0.05)。结论:血府逐瘀汤结合常规西医治疗能够有效提升急性加重期COPD患者的肺功能,并减少炎症因子的水平,为COPD患者的综合治疗提供了一种新的有效方案。
Objective:Evaluate the effect of Xuefu Zhuyu Tang combined with conventional Western medicine treatment on lung function and inflammatory markers in patients with Acute Aggravated chronic obstructive pulmonary disease(COPD)Patients.Method:This study,conducted from October 2020to June 2023in our hospital's respiratory department,involved 82patients with Acute Aggravated COPD Patients.Using a random number table method,patients were divided into two groups:a control group(41patients)who received only conventional Western medical treatment,and an observation group(41patients)who received a combination of conventional Western medical treatment and Xuefu Zhuyu Decoction.The clinical efficacy,Traditional Chinese Medicine(TCM)syndrome scores,pulmonary function indicators[Forced Vital Capacity(FVC),Forced Expiratory Volume in One Second(FEV1),and Diffusing Capacity of the Lung for Carbon Monoxide(DLCO)],and inflammatory markers[White Blood Cell count(WBC),Interleukin-6(IL-6),Leukotriene B4(LT-B4),High Sensitivity C-Reactive Protein(hs-CRP)]were compared between the two groups before and after treatment.Results:The overall effectiveness of the observation group's treatment was notably high at 90.24%(37out of 41patients),substantially surpassing the 73.17%efficacy(30out of 41patients)observed in the control group.This difference was statistically significant(P<0.05).Prior to the commencement of treatment,both groups showed no significant differences in any of the measured indicators(P>0.05).However,post-treatment,the Traditional Chinese Medicine(TCM)syndrome scores in the observation group were markedly lower compared to the control group(P<0.05).Additionally,the Forced Vital Capacity(FVC)and Forced Expiratory Volume in one second(FEV1)were significantly higher in the observation group than in the control group(P<0.05).The Diffusing Capacity of the Lungs for Carbon Monoxide(DLCO)showed no significant statistical difference between the groups(P>0.05).Furthermore,the levels of inflammatory markers in the observation group we
作者
郑艳华
谢亮亮
宋春芳
ZHENG Yanhua;XIE Liangliang;SONG Chunfang(Department of Pulmonary Diseases,Guoyang County Hospital of Traditional Chinese Medicine,Guoyang Anhui 233600,China;Department of Traditional Chinese Medicine,Guoyang Anhui 233600,China;Department of Infection,Guoyang County Hospital of Traditional Chinese Medicine,Guoyang Anhui 233600,China)
出处
《四川中医》
2024年第4期131-135,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
血府逐瘀汤
慢性阻塞性肺病
肺功能
炎症因子
Xuefu Zhuyu Tang
Chronic obstructive pulmonary disease
Lung function
Inflammatory factors
