摘要
违禁药物以微量、痕量甚至超痕量的水平,广泛分布于生物、食品、环境和药物等复杂基质,可能会造成急性中毒、慢性中毒、毒品滥用等问题,违禁药物分析是公共安全领域一直以来的关注焦点。固相萃取是分析复杂基质中违禁药物常用的前处理技术,但萃取痕量级别违禁药物时,易出现样品利用率低、萃取灵敏度差等问题,难以满足公共安全领域灵敏快速的分析需求。为此,具有强大尺寸优势的纳米纤维、纳米颗粒等材料,用于固相萃取技术的开发和创新。静电纺丝技术是连续、大量生产纳米纤维最常用的方法,具有工艺简单、材料多样、纤维尺寸可控等优势,现已广泛用于分析萃取领域。静电纺丝技术经历了从采用单一聚合物纺丝,到多种聚合物混纺、添加功能材料的纳米颗粒修饰等发展,制备的静电纺丝纳米纤维机械性、选择性和稳定性均逐渐提升,拓宽了该技术在违禁药物分析中的适用范围。目前,静电纺丝技术在违禁药物固相萃取中的应用仍属起步阶段,本文系统地综述了静电纺丝在传统固相萃取、微型化固相萃取和分散固相萃取中的研究现状,并对未来可能的发展方向提供了建议,以期为相关问题的深入研究提供参考。
Illicit drugs are widely distributed in complex substrates such as biology,food,environment and drugs at minor,trace and even ultra-trace levels,which may cause acute poisoning,chronic poisoning,drug abuse and other problems.The analysis of illicit drugs has always been the focus of public safety.Solid phase extraction is a commonly used pretreatment technology for the analysis of illicit drugs in complex substrates.However,when extracting trace level illicit drugs,problems such as low sample utilization rate and poor extraction sensitivity may occur,which are difficult to meet the needs of sensitive and rapid analysis in the field of public safety.To this end,nanofibers,nanoparticles and other materials with strong size advantages are used for optimization and innovation of solid phase extraction technology.Electrospinning technology is the most commonly used method for continuous and mass production of nanofibers.It has the advantages of simple process,diverse materials and con⁃trollable fiber size,and has been widely used in the field of analysis and extraction.The electrospinning technology has experienced the development from spinning with a single polymer to blending with a variety of polymers and modifying nanoparticles with functional materials.The mechanical properties,selectivity and stability of the electro⁃spinning nanofibers prepared have also been gradually improved,broadening the application scope of this technology in the analysis of illicit drugs.At present,the application of electrospinning technology in solid phase extraction of illicit drugs is still in its infancy.This paper systematically reviews the research status of electrospinning in tradition⁃al solid phase extraction,micro-solid phase extraction and dispersed solid phase extraction,and provides sugges⁃tions for its possible future development,in order to provide reference for further research on related issues.
作者
牛可歆
廉洁
赵霞
宋树强
苏雪
肖楠
NIU Ke-xin;LIAN Jie;ZHAO Xia;SONG Shu-qiang;SU Xue;XIAO Nan(School of Investigation,People’s Public Security University of China,Beijing 100038,China;National Anti-Drug Laboratory Beijing Regional Center,Beijing 100164,China;Institute of Forensic Science,Tianjin Municipal Public Security Bureau,Tianjin 300380,China)
出处
《药物分析杂志》
CAS
CSCD
北大核心
2024年第4期553-561,共9页
Chinese Journal of Pharmaceutical Analysis
基金
双一流建设科研项目:中国人民公安大学刑事科学技术双一流创新研究专项(2023SYL06)。
关键词
违禁药物
固相萃取
静电纺丝
静电纺丝纳米纤维
金属有机框架
固定相材料
复合纳米纤维
illicit drugs
electrospinning
solid-phase extraction
electrospinning nanofibers
metal-organic framework
stationary phase material
composite nanofiber
