摘要
目的:探究加味四妙汤联合地塞米松治疗痛风性关节炎患者的临床效果。方法:回顾性选取2021年6月—2023年6月厦门市中医院收治的86例痛风性关节炎患者。根据治疗方案的不同将其分为单一组和联合组,各43例。两组均给予基础治疗,单一组给予地塞米松,联合组在单一组基础上给予加味四妙汤。比较两组临床疗效,治疗前后中医症候积分、疼痛程度、实验室指标、炎症因子、免疫功能及不良反应。结果:联合组总有效率为90.70%,高于单一组的74.42%,差异有统计学意义(P<0.05)。治疗后,两组主症、次症、视觉模拟评分法(VAS)评分均低于治疗前,联合组主症、次症、VAS评分均低于单一组,差异有统计学意义(P<0.05)。治疗后,两组血尿酸、血沉、C反应蛋白(CRP)水平均低于治疗前,联合组血尿酸、血沉、CRP水平均低于单一组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)水平均低于治疗前,联合组IL-1β、TNF-α、PCT水平均低于单一组,差异有统计学意义(P<0.05)。治疗后,两组免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白E(IgE)水平均低于治疗前,联合组IgM、IgA、IgE水平均低于单一组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味四妙汤联合地塞米松治疗痛风性关节炎的效果确切,可改善临床症状,减轻疼痛程度,抑制炎症反应,纠正免疫功能失衡状态,且具有一定安全性。
Objective:To explore the effect of modified Simiao Decoction combined with Dexamethasone in the treatment of patients with gouty arthritis.Method:A total of 86 patients with gouty arthritis admitted to Xiamen Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were retrospectively selected.They were divided into single group and combined group according to different treatment plans,with 43 cases in each group.Both groups were given basic treatment,the single group was given Dexamethasone,and the combined group was given modified Simiao Decoction on the basis of single group.The clinical efficacy,traditional Chinese medical syndrome score,pain degree,laboratory indexes,inflammatory factors,immune function before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of combined group was 90.70%,which was higher than 74.42%of single group,and the difference was statistically significant(P<0.05).After treatment,the scores of main disease,secondary disease and visual analogue scale(VAS)in the two groups were lower than those before treatment,and the scores of main disease,secondary disease and VAS in the combined group were lower than those in the single group,the differences were statistically significant(P<0.05).After treatment,the levels of serum uric acid,erythrocyte sedimentation rate and C-reactive protein(CRP)in the two groups were lower than those before treatment,and the levels of serum uric acid,erythrocyte sedimentation rate and CRP in combined group were lower than those in single group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and procalcitonin(PCT)in the two groups were lower than those before treatment,and the levels of IL-1β,TNF-α and PCT in combined group were lower than those in single group,the differences were statistically significant(P<0.05).After treatment,the levels of immunoglobulin M(IgM),immunoglobulin A(IgA)and immunog
作者
黄秋明
HUANG Qiuming(Xiamen Hospital of Traditional Chinese Medicine,Xiamen 361000,China)
出处
《中外医学研究》
2024年第15期1-5,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
痛风性关节炎
加味四妙汤
地塞米松
炎症
免疫功能
Gouty arthritis
Modified Simiao Decoction
Dexamethasone
Inflammation
Immunologic function
