摘要
肿瘤患者在其病程及治疗过程中肾脏疾病的管理存在亟待解决的临床难点。为了协助参与肿瘤药物治疗的医疗专业人员有效应对肿瘤患者治疗中各种肾脏问题,日本肾脏病学会、日本临床肿瘤学会、日本医学肿瘤学会和日本肾脏病药物治疗学会共同制订了《抗肿瘤药物治疗期间肾损伤管理临床实践指南(2022)》。该指南涵盖接受抗肿瘤药物治疗患者的肾功能评估、药源性肾毒性的管理、抗肿瘤药物治疗方案制订,以及肿瘤幸存者慢性肾脏病治疗等内容,形成了11条临床问题及4条良好实践声明,并对相关的临床背景知识进行了16条评论。本文首先对该指南中的临床问题及良好实践声明进行解读,希望有助于对该指南的理解,并对临床实践提供借鉴。
Kidney disease management is a great concern that needs to be addressed urgently in cancer patients during their disease course and treatment process.To help medical professionals involved in cancer pharmacotherapy cope with various kidney issues during the whole management course of cancer patients,the Japanese Society of Nephrology,Japan Society of Clinical Oncology,Japanese Society of Medical Oncology,and Japanese Society of Nephrology and Pharmacotherapy have formulated the Clinical Practice Guidelines for Management of Kidney Injury During Anticancer Drug Therapy 2022.These guidelines cover renal function assessment,management of drug‑induced nephrotoxicity,anticancer drug regimen planning,and chronic kidney disease treatment in cancer survivors and include 11 clinical questions and 4 good practice statements.In addition,these guidelines also comprise 16 general reviews that explain background questions.This article interprets the clinical questions and good practice statements,aiming to facilitate the understanding of these guidelines which may do some help in improving clinical practice.
作者
郑茜子
徐菱忆
周庆庆
杨莉
Zheng Xizi;Xu Lingyi;Zhou Qingqing;Yang Li(Renal Division,Peking University First Hospital,Institute of Nephrology,Peking University,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of CKD Prevention and Treatment,Ministry of Education of China,Research Units of Diagnosis and Treatment of Immune‑Mediated Kidney Diseases,Chinese Academy of Medical Sciences,Beijing 100034,China)
出处
《药物不良反应杂志》
CSCD
2024年第5期261-267,共7页
Adverse Drug Reactions Journal
基金
国家自然科学基金(82300764,82130021)
北京市科技新星计划(2021051)
中央高校基本科研业务费,北京大学临床科学家计划(BMU2023PYJH023)
北京大学临床医学+X青年专项(BMU2023PYJH023)
中央高水平医院临床科研业务费,北京大学第一医院跨学科交叉研究专项(2023IR14)
首都卫生发展科研专项(2022‑1‑4071)。
关键词
抗肿瘤药物
急性肾损伤
肾功能不全
指南
解读
Antineoplastic agents
Acute kidney injury
Renal insufficiency
Guideline
Interpretation
