摘要
目的研究缩宫素联合欣母沛治疗产后出血的临床效果。方法随机对照研究。抽取2019年1月至2022年12月周口市妇幼保健院收治的产后出血患者72例,按随机数字表法分为对照组与研究组,每组36例。对照组采用缩宫素治疗,研究组在对照组基础上联用欣母沛治疗。对比两组临床疗效、产后出血量和宫底高度、子宫收缩功能、凝血因子[凝血酶原时间(PT)、D-二聚体(D-D)纤维蛋白原(FIB)]水平及氧化应激指标[过氧化氢酶(CAT)、丙二醛(MDA)]。结果研究组总有效率(94.44%,34/36)高于对照组(72.22%,26/36),P<0.05。产后2、12、24 h,研究组出血量少于对照组,产后宫底高度低于对照组(P<0.05);研究组子宫收缩持续时间长于对照组,子宫底下降速度快于对照组(P<0.05)。治疗后,研究组PT、D-D、FIB水平低于对照组(P<0.05);治疗后,研究组CAT水平高于对照组,MDA水平低于对照组(P<0.05)。结论缩宫素联合欣母沛治疗产后出血效果显著,能减少出血量,促进子宫收缩,改善机体凝血指标和氧化应激反应。
Objective To investigate the effect of oxytocin combined with hemabate in the treatment of postpartum hemorrhage.Methods A total of 72 patients with postpartum hemorrhage admitted to Zhoukou Maternal and Child Health Hospital from January 2019 to December 2022 were selected for the randomized controlled study.And they were divided into a control group and a study group using a random number table method,with 36 cases in each group.The control group was treated with oxytocin,and the study group was treated with hemabate based on the treatment of the control group.The curative effect,postpartum hemorrhage volume,height of the fundus of uterus,uterine contractions,levels of coagulation factors,including prothrombin time(PT),D-dimer(D-D)and fibrinogen(FIB),and oxidative stress indicators,including catalase(CAT),malondialdehyde(MDA),were compared between the two groups.Results The total effective rate of the study group(94.44%,34/36)was higher than that of the control group(72.22%,26/36),P<0.05.At 2,12,and 24 hours after delivery,the study group had less bleeding and lower postpartum height of the fundus of uterus compared with the control group(P<0.05).The duration of uterine contractions in the study group was longer than that in the control group,while the rate of uterine floor descent was faster than that in the control group(P<0.05).After treatment,the levels of PT,D-D and FIB in the study group were lower than those in the control group(P<0.05).After treatment,the CAT level in the study group was higher than that in the control group,while MDA level was lower than that in the control group(P<0.05).Conclusions The effect of oxytocin combined with hemabate in the treatment of postpartum hemorrhage is significant,which can reduce the amount of bleeding,promote uterine contractions,improve coagulation indicators and oxidative stress responses.
作者
陆小丽
张小琴
崔晨曦
许莹莹
李梦珠
Lu Xiaoli;Zhang Xiaoqin;Cui Chenxi;Xu Yingying;Li Mengzhu(Department of Obstetrics,Zhoukou Maternal and Child Health Hospital,Zhoukou Children’s Hospital,Zhoukou 466000,China;Department of Gynaecology and Obstetrics,Shangshui People’s Hospital,Shangshui 466100,China;Department of Delivery Room,Zhoukou Maternal and Child Health Hospital,Zhoukou Children’s Hospital,Zhoukou 466000,China)
出处
《中国实用医刊》
2024年第4期103-106,共4页
Chinese Journal of Practical Medicine
关键词
产后出血
缩宫素
欣母沛
Postpartum hemorrhage
Oxytocin
Hemabate
