摘要
目的比较艾司奥美拉唑+阿莫西林大剂量二联方案与含铋剂常规四联方案治疗幽门螺杆菌(HP)感染初治患者的效果及安全性。方法随机对照研究。抽取2021年1月至2022年12月于晋城市人民医院消化内科就诊的HP感染初治患者200例,按照随机数字表法分为二联组和四联组,每组100例,后二联组剔除11例、四联组剔除6例。二联组予以大剂量艾司奥美拉唑+阿莫西林治疗,四联组予以常规艾司奥美拉唑+阿莫西林+胶体果胶铋+呋喃唑酮治疗。比较两组患者的HP根治率、治疗依从性、不良反应发生率及治疗费用等指标。结果二联组HP根除率为84.27%(75/89),稍低于四联组的87.23%(82/94),但差异未见统计学意义(P=0.566)。二联组治疗依从性良好率(88.76%,79/89)高于四联组(76.60%,72/94),差异有统计学意义(P=0.030)。二联组患者药物相关不良反应总发生率(17.98%,16/89)与四联组(23.40%,22/94)比较,差异未见统计学意义(P=0.366)。二联组患者的治疗费用[(883.56±95.47)元]高于四联组[(779.38±81.25)元],差异有统计学意义(P<0.001)。结论艾司奥美拉唑、阿莫西林大剂量二联方案治疗HP感染初治患者的HP根治率、不良反应与常规四联方案一致,但治疗依从性更高。
Objective To compare the efficacy and safety of dual therapy with high-dose esomeprazole and amoxicillin versus the conventional bismuth-containing quadruple therapy for Helicobacter pylori(HP)infection in previously untreated patients.Methods A total of 200 previously untreated patients with HP infection who visited Department of Gastroenterology in Jincheng People’s Hospital from January 2021 to December 2022 were selected for the randomized controlled study.And they were divided into the dual therapy group and the quadruple therapy group by random number table method,with 100 cases in each group.In final,11 cases were removed from the dual therapy group,and 6 cases were removed from the quadruple therapy group.The dual therapy group was treated with high-dose esomeprazole+amoxicillin,and the quadruple therapy group was treated with conventional esomeprazole+amoxicillin+colloidal bismuth pectin+furazolidone.The eradication rate of HP,treatment compliance rate,incidence of adverse reactions and treatment costs were compared between the two groups.Results The eradication rate of HP in the dual therapy group was 84.27%(75/89),slightly lower than the 87.23%(82/94)in the quadruple therapy group,but the difference was not statistically significant(P=0.566).The good compliance rate of the dual therapy group(88.76%,79/89)was higher than that of the quadruple therapy group(76.60%,72/94),and the difference was statistically significant(P=0.030).There were significant differences in the total incidence of drug-related adverse reactions between the dual therapy group(17.98%,16/89)and the quadruple therapy group(23.40%,22/94),P=0.366.The treatment costs of the dual therapy group was(883.56±95.47)yuan,higher than the(779.38±81.25)yuan of the quadruple therapy group(P<0.001).Conclusions The double therapy of high-dose esomeprazole and amoxicillin in the treatment of previously untreated patients with HP infection has the same eradication rate and adverse reactions as the conventional quadruple therapy,but the treatment co
作者
梁素花
范学科
张妮娜
Liang Suhua;Fan Xueke;Zhang Nina(Department of Gastroenterology,Jincheng People’s Hospital,Jincheng 048000,China)
出处
《中国实用医刊》
2024年第4期99-102,共4页
Chinese Journal of Practical Medicine
