摘要
戊型肝炎病毒(hepatitis E virus,HEV)是一种引发全球急性病毒性肝炎的人兽共患病病原。HEV具有丰富的遗传多样性,不同基因型或基因亚型的流行与地理位置、宿主物种以及防控策略等密切相关。欧洲和美洲HEV流行株为HEV-3,包括3a-3i亚型,而亚洲流行株含HEV-3和HEV-4;我国的流行毒株已从HEV-1进化到HEV-4。近年来,研究发现HEV进化的影响机制,包括同义密码子使用模式、氨基酸突变和基因重组等,其中氨基酸突变是病毒持续流行的主要驱动力。因此,本文就HEV的分类、全球流行特征、进化机制等进行综述,以期为戊型肝炎的有效防控以及疫苗开发提供参考。
Hepatitis E virus(HEV)is a major zoonotic pathogen that causes acute viral hepatitis worldwide.HEV has high genetic diversity,and the incidence of various genotypes or subtypes is strongly correlated with host species,geographic location,and prevention and control methods.HEV strains HEV-3,comprising 3a–3i subtypes,were present in Europe and America,whereas HEV-3 and HEV-4 were prevalent in Asia.The epidemic strains in China have evolved from HEV-1 to HEV-4.Recent studies have shown that gene recombination,amino acid mutations,and synonymous codon usage patterns are part of the mechanisms underlying HEV evolution.In particular,amino acid mutations are the main driving force for the continued prevalence of the virus.This paper reviews the classification,global epidemic characteristics,and evolutionary mechanism of HEV,aiming to provide a reference for the prevention and control of hepatitis E and vaccine development.
作者
徐永权
高珺珊
吴清平
张菊梅
薛亮
XU Yongquan;GAO Junshan;WU Qingping;ZHANG Jumei;XUE Liang(College of Food Science,South China Agricultural University,Guangzhou 510642,Guangdong,China;National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food,Guangdong Provincial Key Laboratory of Microbial Safety and Health,State Key Laboratory of Applied Microbiology Southern China,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070,Guangdong,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2024年第5期1392-1401,共10页
Acta Microbiologica Sinica
基金
国家重点研发计划(2022YFF1103100)
国家自然科学基金(32272436)
广东省重点研发计划(2022B1111040002)。
关键词
戊型肝炎病毒
遗传多样性
进化
hepatitis E virus
genetic diversity
evolution
