摘要
目的为了进一步评估胫骨骨膜牵张术联合人表皮生长因子(5万IU/10 g)外用治疗糖尿病足溃疡的疗效,我们开展了本次研究,以期为医生治疗糖尿病足溃疡提供参考。方法对2021年1月至2023年10月在我院烧伤整形外科采用胫骨骨膜牵张术联合人表皮生长因子(5万IU/10 g)外用治疗的30例糖尿病足溃疡患者进行回顾性分析。通过对比患者术前术后的患侧足趾血氧饱和度、患足足部皮温、患足踝肱指数及糖尿病足创面愈合情况来评价治疗方法的疗效。结果患者术前足趾血氧饱和度为(79.97±1.44)%,术后足趾血氧饱和度为(92.32±1.70)%,糖尿病足溃疡患者经过胫骨骨膜牵张术联合人表皮生长因子(5万IU/10 g)外用治疗的后足趾血氧饱和度明显改善(P<0.05)。患者术前患足足部皮温为(28.05±0.63)℃,术后患足足部皮温为(30.83±0.70)℃,经过治疗的糖尿病足溃疡患者的术后患足足部皮温明显提高(P<0.05)。患者术前患足踝肱指数为0.65±0.04,术后患足踝肱指数为0.73±0.02,经过治疗的糖尿病足溃疡患者的患足踝肱指数明显改善(P<0.05)。经过治疗,糖尿病足溃疡患者的创面完全愈合率达93.33%。结论胫骨骨膜牵张术联合人表皮生长因子(5万IU/10 g)外用治疗糖尿病足溃疡的治疗效果显著,对患者足趾血氧饱和度、患足足部皮温、患足踝肱指数有明显改善,创面完全愈合率高,值得在糖尿病足溃疡的临床治疗中推广应用。
Objective In order to evaluate the efficacy of tibial periosteal distraction combined with human epidermal growth factors(50000 IU/10 g)in the treatment of diabetic foot ulcers,we conducted this study,hoping to provide a reference for doctors in the treatment of diabetic foot ulcers.Methods A retrospective study was conducted on 30 patients with diabetic foot ulcers treated with tibial periosteal distraction combined with human epidermal growth factors(50000 IU/10 g)from January 2021 to October 2023.The effect of the treatment was evaluated by comparing the blood oxygen saturation of affected lateral toe,full skin temperature,ankle brachial index and wound healing of diabetic foot before and after surgery.Results The blood oxygen saturation of affected lateral toe was(79.97±1.44)%before surgery and(92.32±1.70)%after surgery,we found that after tibial periosteal distraction combined with human epidermal growth factors(50000 IU/10 g)treatment,the blood oxygen saturation of affected lateral toe was significantly improved(P<0.05).The preoperative skin temperature was(28.05±0.63)℃and the postoperative skin temperature was(30.83±0.70)℃.The postoperative skin temperature of patients with diabetic foot ulcers was significantly increased after treatment(P<0.05).The preoperative ankle brachial index was 0.65±0.04,and the postoperative ankle brachial index was 0.73±0.02.After treatment,the ankle brachial index of patients with diabetic foot ulcers improved significantly(P<0.05).After treatment,the wound healing rate of patients with diabetic foot ulcers was 93.33%.Conclusion Tibial periosteal distraction combined with human epidermal growth factors(50000 IU/10 g)was effective in the treatment of diabetic foot ulcers.It is worth popularizing and applying in the clinical treatment of diabetic foot ulcers.
作者
王春雷
张波
朱俊晖
车志丽
苏永涛
Wang Chunlei;Zhang Bo;Zhu Junhui;Che Zhili;Su Yongtao(First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan Shandong 250355,China;Department of Burn Skin Surgery,PKU Care Luzhong Hospital,Zibo Shandong 255400,China;Institute of Tissue Regeneration and Wound Repair,Shandong University of Traditional Chinese Medicine,Jinan Shandong 250355,China)
出处
《遵义医科大学学报》
2024年第6期610-614,共5页
Journal of Zunyi Medical University
关键词
骨膜牵张术
糖尿病足溃疡
表皮生长因子
推广应用
tibial periosteal distraction
diabetic foot ulcer
human epidermal growth factors
popularization and application
