摘要
星形胶质细胞(astrocyte,AS)是中枢神经系统最丰富的神经胶质细胞,其参与神经系统诸多生理和病理过程。其表型的改变对中枢神经系统的健康尤为重要。表观遗传学机制包括DNA甲基化、组蛋白修饰、非编码RNA调控和染色质重塑等,皆与AS增殖、分化、炎症等表型特征的改变紧密联系,但这些机制如何发挥作用仍需要探索与总结。通过综述在不同的生理和病理状态下表观遗传学机制对AS作用的最新进展,以期为相关疾病的认识和治疗提供新思路。
Astrocytes(AS)are the most abundant glial cells in the central nervous system and are involved in many physiological and pathological processes in the nervous system.Alterations in their phenotype are particularly important for the health of the CNS.Epigenetic mechanisms,including DNA methylation,histone modification,non-coding RNA regulation,and chromatin remodeling,are closely linked to alterations in AS proliferation,differentiation,inflammation,and other phenotypic features,but how these mechanisms function needs to be explored and summarized.By reviewing the recent advances in the role of epigenetic mechanisms in AS under various physiological and pathological states,we aim to provide new ideas for the understanding and treatment of related diseases.
作者
徐柳清
赵培源
刘喜红
杜晓丹
范孟杨
侯俊林
XU Liuqing;ZHAO Peiyuan;LIU Xihong;DU Xiaodan;FAN Mengyang;HOU Junlin(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国比较医学杂志》
CAS
北大核心
2024年第5期126-133,共8页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(82104579)
中国博士后科学基金面上项目(2023M731024)
河南省自然科学基金(202300410258)
河南省高等学校青年骨干教师培养计划(2023GGJS080)
河南省科技攻关(242102310497)。
关键词
星形胶质细胞
表观遗传学
甲基化
组蛋白修饰
非编码RNA
astrocyte
epigenetic
methylation
histone modification
non-coding RNA Conflicts of Interest:The authors declare no conflict of interest
