摘要
急性肾损伤(acute kidney injury,AKI)是一个全球性的公共卫生问题,其发病率和病死率高、医疗费用昂贵且治疗手段有限。AKI可进一步转变为慢性肾脏病(chronic kidney disease,CKD),最终进展为终末期肾病(endstage renal disease,ESRD)。既往研究表明,创伤、药物的不良反应、手术等与AKI密切相关。随着进一步的深入探索,肠道菌群在AKI中的作用逐渐被揭示。AKI发生后,肠道菌群组成改变,肠道屏障破坏引发肠道免疫以及肠道细菌易位。同时,肠道菌群的代谢产物又可以加剧AKI的进展。因此,阐述肠道菌群参与AKI发生和发展的具体机制,有助于从肠道微生物角度为AKI的防治提供新思路。
Acute kidney injury(AKI)remains a global public health problem with high incidence,high mortality rates,expensive medical costs,and limited treatment options.AKI can further progress to chronic kidney disease(CKD)and eventually end-stage renal disease(ESRD).Previous studies have shown that trauma,adverse drug reactions,surgery,and other factors are closely associated with AKI.With further in-depth exploration,the role of gut microbiota in AKI is gradually revealed.After AKI occurs,there are changes in the composition of gut microbiota,leading to disruption of the intestinal barrier,intestinal immune response,and bacterial translocation.Meanwhile,metabolites of gut microbiota can exacerbate the progression of AKI.Therefore,elucidating the specific mechanisms by which gut microbiota is involved in the occurrence and development of AKI can provide new insights from the perspective of intestinal microbiota for the prevention and treatment of AKI.
作者
陈天笑
常畅
侯豹
邱丽颖
孙海建
朱雪雪
CHEN Tianxiao;CHANG Chang;HOU Bao;QIU Liying;SUN Haijian;ZHU Xuexue(Department of Basic Medicine,Wuxi Medical College,Jiangnan University,Wuxi Jiangsu 214122,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2024年第3期385-391,共7页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(82300414)
江苏省自然科学基金(BK20231049)。
关键词
急性肾损伤
肠道菌群
炎症
毒素
短链脂肪酸
益生菌
后生元
中药
acute kidney injury
gut microbiota
inflammation
toxins
short-chain fatty acids
probiotic
postbiotics
traditional Chinese medicine
