摘要
胃癌是全世界最常见的癌症之一,给人们的生命健康带来巨大的威胁。由于胃癌缺乏特异性临床表现及预防筛查的不重视,90%的患者发现时已进展为晚期,晚期以化疗和靶向治疗为主,但随着化疗及靶向药物的长期应用,肿瘤的抗药性显现,胃癌细胞重新获得增殖、转移及侵袭能力,从而最终导致患者的死亡。胃癌化疗耐药涉及多种复杂机制,代谢紊乱在肿瘤耐药机制中起到重要作用,靶向代谢的化疗一直是有效的治疗癌症的方法。靶向治疗相对于化疗具有疗效佳及副作用小的特点,但其个体差异大,临床应用范围有限。因而寻找更丰富、更有效的靶点对于胃癌的治疗具有重要的意义。代谢重编程被认为是癌症的标志之一,代谢重编程为肿瘤细胞提供代谢需求,肿瘤代谢异常在肿瘤的发生、转移、耐药和肿瘤干细胞中都起到重要作用。癌基因和抑癌基因对细胞的代谢有重要影响,一些治疗肿瘤的方法已经集中在靶向癌细胞的代谢上,并取得一定疗效。胃癌相关代谢性的治疗靶点也在不断的丰富,针对胃癌代谢性靶点的探索有可能为胃癌的治疗带来新的希望。文章将系统阐述胃癌代谢性改变与治疗靶点的研究进展,为胃癌的临床治疗提供一定的参考。
Gastric cancer is one of the most common cancers in the world,which brings great threat to people's life and health.Due to the lack of specific clinical manifestations of gastric cancer and the lack of attention to preventive screening,90%of patients have advanced to the advanced stage when they are found,mainly chemotherapy and targeted therapy.However,with the long-term application of chemotherapy and targeted drugs,tumor resistance appears,and gastric cancer cells regain the ability of proliferation,metastasis and invasion,which ultimately leads to the death of patients.Chemotherapy resistance of gastric cancer involves a variety of complex mechanisms,and metabolic disorders play an important role in the mechanism of tumor drug resistance.Chemotherapy targeting metabolism has always been an effective method to treat cancer.Compared with chemotherapy,targeted therapy has the characteristics of better efficacy and less side effects,but its individual differences are large,and the clinical application range is limited.Therefore,it is of great significance to search for more abundant and effective targets for the treatment of gastric cancer.Metabolic reprogramming is considered to be one of the hallmarks of cancer.Metabolic reprogramming provides metabolic requirements for tumor cells,and abnormal tumor metabolism plays an important role in tumor genesis,metastasis,drug resistance and tumor stem cells.Oncogenes and tumor suppressor genes have important effects on cell metabolism,and some methods of tumor treatment have been focused on targeting the metabolism of cancer cells,and have achieved certain efficacy.The therapeutic targets of gastric cancer related metabolism are also continuously enriched,and the exploration of metabolic targets for gastric cancer may bring new hope for the treatment of gastric cancer.In this paper,the research progress of metabolic changes and therapeutic targets of gastric cancer will be systematically reviewed,so as to provide certain references for clinical treatment of gastric canc
作者
何砺坚
朱娟娟
陈一砾
HE Li-jian;ZHU Juan-juan;CHEN Yi-shuo(Jiangsu University,Zhenjian 212000,China;Department of Nephrology,the 2nd Affiliated of Harbin Medical University,Harbin 150000,China)
出处
《药物生物技术》
CAS
2024年第1期99-102,共4页
Pharmaceutical Biotechnology
关键词
胃癌
糖代谢
氨基酸代谢
脂代谢
治疗靶点
Gastric cancer
Glucose metabolism
Amino acid metabolism
Lipid metabolism
Therapeutic target
