摘要
目的:通过Meta分析研究骨髓炎患者中耐甲氧西林金黄色葡萄球菌(MRSA)的感染率。方法:检索PubMed、Web of Science、中国知网、维普、万方和中国生物医学文献数据库(CBM)关于骨髓炎患者MRSA感染率的研究,检索时限为建库至2023年8月。由2位研究人员按照纳入与排除标准对所获文献独立进行筛选、提取,采用纽卡斯尔-渥太华量表评分(NOS)进行文献质量评价。以感染率为结局指标合并数据,采用R(4.3.1)进行Meta分析,并根据骨髓炎类型、患者年龄、研究地区进行亚组分析。结果:共纳入26篇文献,共包含20860名骨髓炎患者。Meta分析结果显示,骨髓炎患者MRSA感染率为0.240(95%CI:0.183~0.297)。亚组分析结果显示,椎体骨髓炎(VO)患者、18~60岁、北美地区骨髓炎患者的MRSA感染率更高。结论:骨髓炎患者中MRSA的感染率较高,需采取有效的预防和控制措施减少MRSA的传播。
Objective:To study the prevalence of methicillin resistant Staphylococcus aureus(MRSA)infection in patients with osteomyelitis by meta-analysis.Methods:PubMed,Web of Science,CNKI,VIP,Wanfang,and CBM were searched for Prevalence of MRSA infection in patients with osteomyelitis from inception to August 2023.The data were independently screened and extracted by 2 investigators according to the inclusion and exclusion criteria and the quality of literature was evaluated using the NOS.Data were combined using prevalence as an outcome indicator,and meta-analysis was conducted using R(4.3.1)software with subgroup analysis based on types of osteomyelitis,age and research region.Results:A total of 26 papers containing 20860 patients with osteomyelitis were included.Meta-analysis showed that the combined prevalence of MRSA infection in patients with osteomyelitis was 0.240(95%CI:0.183~0.297).Subgroup analyses showed a higher prevalence of MRSA infection in patients with VO,aged 18~60 years,and in patients with osteomyelitis in North America.Conclusion:The prevalence of MRSA infection is high in patients with osteomyelitis,and effective prevention and control measures are needed to reduce the transmission of MRSA.
作者
王鸿伟
田芳英
赵明
王雪玉
张翰笙
崔欣雨
WANG Hongwei;TIAN Fangying;ZHAO Ming;WANG Xueyu;ZHANG Hansheng;CUI Xinyu(Nursing College,the Second Hospital of Shanxi Medical University,Shanxi Medical University,Taiyuan 030001,Shanxi,China;Department of Nosocomial Infection Management,the Second Hospital of Shanxi Medical University,Shanxi Medical University,Taiyuan 030001,Shanxi,China;Department of Infectious Diseases,First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang,China)
出处
《暨南大学学报（自然科学与医学版）》
CAS
北大核心
2024年第2期168-175,共8页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
山西省软科学研究项目(2017041037-2)。
