摘要
目的 观察左卡尼汀(LC)联合胞二磷胆碱(CDPC)对新生儿缺氧缺血性脑病(HIE)的保护作用。方法 选取2019年8月至2023年8月青海省西宁市第二人民医院就诊的HIE患儿98例,根据随机数字表法将其分为对照组(CDPC治疗)、试验组(LC联合CDPC治疗),各49例。两组均治疗14 d,比较两组恢复情况、治疗效果及不良反应;比较两组治疗前后血清肌酸激酶同工酶-MB(CK-MB)、神经元特异性烯醇化酶(NSE)、S100B、内皮素-1(ET-1)、脂氧素A4(LXA4)水平。结果 试验组惊厥停止、反射恢复、肌张力恢复、意识恢复时间短于对照组(P<0.05)。试验组临床疗效优于对照组(P<0.05)。治疗后,两组血清CK-MB、NSE、S100B、ET-1水平低于治疗前,且试验组低于对照组(P<0.05);两组LXA4水平高于治疗前,且试验组高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 LC联合CDPC可加快HIE恢复,提升治疗效果,降低血清CK-MB、NSE、S100B、ET-1水平,提高LXA4水平,且安全可靠。
Objective To observe the protective effect of L-carnitine(LC) combined with Cytidine Diphosphate Choline(CDPC) on neonatal hypoxic-ischemic encephalopathy(HIE).Methods A total of 98 children patients with HIE were selected from the Second People's Hospital of Xining,Qinghai Province from August 2019 to August 2023 were selected,and they were divided into control group(CDPC treatment) and experimental group(LC combined with CDPC treatment),with 49 cases in each group.Both groups were treated for 14 days,and the recovery situation,therapeutic effect,and adverse reactions of two groups were compared;the serum levels of creatine kinase isoenzyme-MB(CK-MB),neuron-specific enolase(NSE),S100B,endothelin-1(ET-1),and lipoxinA4(LXA4) were compared before and after treatment.Results The time of convulsion stop,reflex recovery,muscle tone recovery,and consciousness recovery in experimental group was shorter than that in control group(P<0.05).The clinical effect of experimental group was better than that of control group(P<0.05).After treatment,the serum levels of CK-MB,NSE,S100B,and ET-1 in two groups were lower than those before treatment,and those in experimental group were lower than those in control group(P<0.05);the level of LXA4 in both groups was higher than that before treatment,and that in experimental group was higher than that in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion LC combined with CDPC can accelerate the recovery of HIE,improve the therapeutic effect,reduce the serum levels of CK-MB,NSE,S100B,and ET-1,increase the level of LXA4,and is safe and reliable.
作者
吴娥玲
石润玲
李永玲
韦晓彤
WU Eling;SHI Runling;LI Yongling;WEI Xiaotong(Department of Pediatrics,the Second People’s Hospital of Xining,Qinghai Province,Xining810003,China;Neonatal Intensive Care Unit,Qinghai Women and Children’s Hospital,Qinghai Province,Xining810007,China)
出处
《中国医药导报》
CAS
2024年第15期85-87,91,共4页
China Medical Herald
基金
青海省自然科学基金资助项目(2021-ZJ-751)。
关键词
新生儿
缺氧缺血性脑病
左卡尼汀
胞二磷胆碱
Newborn
Hypoxic-ischemic encephalopathy
L-carnitine
Cytidine Diphosphate Choline
