摘要
血管内皮细胞是内衬在血管内壁表面的单细胞层,活化后可增强肝癌细胞的增殖性和侵袭性,通过增殖、迁移等方式形成新的血管,促使肝癌的复发和转移。微RNA(miRNA)对血管内皮细胞功能具有重要的调节作用,其转录后可抑制或促进血管内皮细胞增殖,影响肝癌患者预后。miR-126、miR-155、miR-21、miR-221/222是常见的几种调控血管内皮细胞功能的miRNA,这些不同种类miRNA可通过不同机制对肝癌患者的血管内皮细胞功能产生影响,从而调控肝癌细胞的增殖和转移。因此,阐明不同种类miRNA调控血管内皮细胞功能的具体机制,将对肝癌的诊断、治疗和预后评估具有重要意义。
Vascular endothelial cells are single-cell layers lined on the inner wall of blood vessels.After activation,they can enhance the proliferation and invasiveness of liver cancer cells,forming new blood vessels through proliferation,migration,and other methods,promoting the recurrence and metastasis of liver cancer.Micro RNA(miRNA) plays an important regulatory role in the function of vascular endothelial cells,and its transcription can inhibit or promote the proliferation of vascular endothelial cells,affecting the prognosis of liver cancer patients.The miR-126,miR-155,miR-21,and miR-221/222 are common miRNAs that regulate endothelial cell function.These different types of miRNAs can affect endothelial cell function in liver cancer patients through different mechanisms,thereby regulating the proliferation and metastasis of liver cancer cells.Therefore,elucidating the specific mechanisms by which different types of miRNAs regulate the function of vascular endothelial cells will be of great significance for the diagnosis,treatment and prognosis evaluation of liver cancer.
作者
王梦楠
毛琦淇
项建强
李宏
WANG Mengnan;MAO Qiqi;XIANG Jianqiang;LI Hong(Department of General Surgery,Li Huili Hospital Affiliated to Ningbo University,Zhejiang Province,Ningbo 315046,China)
出处
《中国医药导报》
CAS
2024年第13期181-183,187,共4页
China Medical Herald
基金
浙江省卫生健康科技计划项目(2022KY1079)。
关键词
肝癌
微RNA
血管内皮细胞
Liver cancer
Micro RNA
Vascular endothelial cell
