摘要
目的探讨重组牛碱性成纤维细胞生长因子滴眼液(商品名:贝复舒)、普拉洛芬共同应用在白内障超声乳化术后角膜水肿患者中的疗效及对其视力的影响。方法选取96例白内障超声乳化术后角膜水肿患者,按照随机法进行分组,分别为对照组、观察组,各48例。对照组患者单独应用普拉洛芬治疗,观察组同时应用贝复舒、普拉洛芬开展治疗。比较两组患者的治疗效果、视力情况、生活质量、不良反应发生率。结果观察组总有效率91.67%比对照组的75.00%高,差异有统计学意义(P<0.05)。治疗后1、4、12周,观察组的视力分别为(0.06±0.07)、(0.05±0.06)、(0.04±0.06),均优于对照组的(0.13±0.11)、(0.09±0.09)、(0.08±0.11),差异有统计学意义(P<0.05)。治疗后,观察组的社会、情绪、躯体、认知、角色功能评分分别为(81.72±20.34)、(89.89±18.56)、(81.45±22.46)、(89.79±14.12)、(89.57±28.46)分,高于对照组的(69.12±22.29)、(78.36±14.24)、(67.37±14.61)、(80.64±19.53)、(74.42±18.27)分,差异有统计学意义(P<0.05)。观察组患者不良反应发生率4.17%与对照组的8.33%比较,差异无统计学意义(P>0.05)。结论贝复舒、普拉洛芬共同应用在白内障超声乳化术后角膜水肿患者中,能够帮助患者改善视力,有效促进其早日康复,值得临床上推广使用。
Objective To explore the efficacy of recombinant bovine basic fibroblast growth factor eye drops combined with pranoprofen on corneal edema after cataract phacoemulsification surgery and its influence on visual acuity.Methods A total of 96 patients with corneal edema after phacoemulsification surgery were randomly divided into a control group and an observation group,with 48 cases in each group.The control group was treated with pranoprofen alone,while the observation group was treated with recombinant bovine basic fibroblast growth factor eye drops and praprofen simultaneously.The treatment effect,visual acuity,quality of life and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.67%,which was higher than the control group's 75.00%,and the difference was statistically significant(P<0.05).At 1,4 and 12 weeks after treatment,the visual acuity of the observation group were(0.06±0.07),(0.05±0.06)and(0.04±0.06)points,which were better than(0.13±0.11),(0.09±0.09)and(0.08±0.11)points in the control group,and the difference was statistically significant(P<0.05).After treatment,the social,emotional,physical,cognitive and role function scores of the observation group were(81.72±20.34),(89.89±18.56),(81.45±22.46),(89.79±14.12)and(89.57±28.46)points,which were higher than(69.12±22.29),(78.36±14.24),(67.37±14.61),(80.64±19.53)and(74.42±18.27)points of the control group.The difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(4.17%)and the control group(8.33%)(P>0.05).Conclusion The combined application of recombinant bovine basic fibroblast growth factor eye drops and praloprofen in patients with corneal edema after cataract phacoemulsification can help patients improve vision and effectively promote their early recovery,which is worthy of clinical promotion.
作者
解娜
王民
XIE Na;WANG Min(Department of Pharmacy,Dongping County Hospital of Traditional Chinese Medicine,Tai'an 271500,China)
出处
《中国现代药物应用》
2024年第10期122-125,共4页
Chinese Journal of Modern Drug Application
关键词
贝复舒
普拉洛芬
白内障
超声乳化术
角膜水肿
视力指标
治疗效果
Recombinant bovine basic fibroblast growth factor eye drops
Pranoprofen
Cataract
Phacoemulsification surgery
Corneal edema
Visual acuity indicators
Treatment effect
