摘要
骨关节炎(OA)历来被认为是一种慢性退行性疾病,关节内多个组织的分解代谢紊乱与OA的发生、发展密切相关。液相色谱-质谱(LC-MS)技术能检测OA中特定的代谢物和相关代谢途径,揭示OA潜在的病理和生理代谢过程。本文对近几年内利用LC-MS技术检测OA中关节软骨、滑膜和脂肪垫样本的代谢结果进行讨论并总结,综述了OA局部组织样本经LC-MS技术检测出的差异代谢物和代谢途径,为LC-MS技术鉴定OA进展相关生物标志物提供理论依据。
Osteoarthritis(OA)has always been considered as a chronic degenerative disease,and the catabolic disorders of multiple tissues in the joint are closely related to the occurrence and development of OA.Liquid chromatography-mass spectrometry(LC-MS)can detect specific metabolites and related metabolic pathways in OA,and reveal the potential pathological and physiological metabolic processes of OA.In this paper,the metabolic results of articular cartilage,synovial membrane,and fat pad samples detected by LC-MS in OA in recent years are discussed and summarized,and the differential metabolites and metabolic pathways detected by LC-MS in OA local tissue samples are reviewed,providing theoretical basis for the identification of biomarkers related to OA progression by LC-MS technology.
作者
刘德仁
廖太阳
吴鹏
茆军
LIU Deren;LIAO Taiyang;WU Peng;MAO Jun(Departments of Orthopedics,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China)
出处
《中国医药导报》
CAS
2024年第10期186-188,共3页
China Medical Herald
基金
国家自然科学基金青年科学基金资助项目(82205143)
江苏省中医院高峰学术人才培养项目(Y2021rc20)
江苏省中医院优秀青年博士培养专项(2023QB0122)
江苏省中医临床优秀人才研修项目
江苏省研究生科研创新计划项目(KYCX23_2141)。
关键词
骨关节炎
液相色谱-质谱
关节软骨
滑膜
脂肪垫
Osteoarthritis
Liquid chromatography-mass spectrometry
Articular cartilage
Synovial membrane
Fat pad
