摘要
目的:探究非小细胞肺癌患者血清长链非编码RNA(lncRNA)及血管内皮生长因子(VEGF)的表达变化及相关性。方法:2020年1月—2023年5月武汉科技大学附属天佑医院收治的90例非小细胞肺癌患者为观察组,同时期收治的40例肺部良性病变患者为对照组。检测及比较两组血清lncRNA(lncRNA H19、lncRNA DANCR及lncRNA ANRIL)及VEGF(VEGF-A、VEGF-C及VEGF-D)的表达水平,并比较观察组中不同性别、年龄、疾病分期、分化程度及淋巴结转移情况患者的血清lncRNA及VEGF表达水平,采用Pearson相关性分析非小细胞肺癌患者上述血清lncRNA与VEGF的相关性。结果:观察组血清lncRNA与血清VEGF均显著高于对照组(P<0.05);观察组中不同疾病分期及淋巴结转移情况患者的血清lncRNA与VEGF比较,差异均有统计学意义(P<0.05);Pearson相关性分析显示,非小细胞肺癌患者的血清lncRNA与VEGF均呈正相关(P<0.05)。结论:非小细胞肺癌患者lncRNA H19、lncRNA DANCR及lncRNA ANRIL及VEGF均呈现高表达状态,且上述lncRNA与VEGF均呈正相关,在非小细胞肺癌早期诊断中具有一定价值。
Objective:To investigate the expression changes and correlation of serum long non-coding RNA(lncRNA)and vascular endothelial growth factor(VEGF)in patients with non-small cell lung carcinoma.Method:A total of 90 patients with non-small cell lung carcinoma admitted to Tianyou Hospital Affiliated to Wuhan University of Science&Technology from January 2020 to May 2023 were included in the observation group,and 40 patients with benign lung lesions admitted during the same period were included in the control group.The expression levels of serum lncRNA(lncRNA H19,lncRNA DANCR and lncRNA ANRIL)and VEGF(VEGF-A,VEGF-C and VEGF-D)were detected and compared between the two groups.The expression levels of serum lncRNA and VEGF in patients with different gender,age,disease staging,differentiation degree and lymph node metastasis situation were compared in the observation group.Pearson correlation was used to analyze the correlation between serum lncRNA and VEGF in patients with non-small cell lung carcinoma.Result:Serum lncRNA and VEGF in observation group were significantly higher than those in control group(P<0.05).There were significant differences in serum lncRNA and VEGF in patients with disease staging and lymph node metastasis situation in the observation group(P<0.05).Pearson correlation analysis showed that serum lncRNA were positively correlated with VEGF in patients with non-small cell lung carcinoma(P<0.05).Conclusion:lncRNA H19,lncRNA DANCR,lncRNA ANRIL and VEGF are all highly expressed in patients with non-small cell lung carcinoma,and the above lncRNA are positively correlated with VEGF,which have certain value in the early diagnosis of non-small cell lung carcinoma.
作者
陈丽丽
李明
王文怡
CHEN Lili;LI Ming;WANG Wenyi(Department of Laboratory,Tianyou Hospital Affiliated to Wuhan University of Science&Technology,Wuhan 430064,China)
出处
《中国医学创新》
CAS
2024年第15期143-147,共5页
Medical Innovation of China
关键词
非小细胞肺癌
长链非编码RNA
血管内皮生长因子
相关性
Non-small cell lung carcinoma
Long non-coding
RNA
Vascular endothelial growth factor
Correlation
