摘要
目的:观察消疣汤联合干扰素治疗湿热下注型宫颈HR-HPV感染伴CINⅠ的临床治疗效果。方法:选取符合诊断标准的80例湿热下注型宫颈HR-HPV感染伴CINⅠ患者,随机平均分为治疗组和对照组,每组40例。对照组使用尤靖安(重组人干扰素α-2b凝胶),治疗组在对照组基础上加用消疣汤外洗,治疗3个月经周期。观察治疗前后两组患者的中医证候积分、临床疗效、HR-HPV转阴率、CINⅠ改善情况,P16/Ki-67在宫颈病变上皮的表达情况。结果:两组治疗后中医证候积分较治疗前明显降低(P<0.01),在中医证候积分、临床疗效、HR-HPV转阴率、CINⅠ改善有效率、P16/Ki-67阳性表达率转阴方面,治疗组显著优于对照组(P<0.05,P<0.01)。结论:消疣汤联合干扰素治疗湿热下注型宫颈HR-HPV感染伴CINⅠ患者的临床效果显著,可明显改善患者中医临床证候表现,促使HR-HPV转阴,逆转CINⅠ进展,降低P16/Ki-67在宫颈上皮细胞中的阳性表达,其疗效优于单一干扰素组,临床意义显著。
Objective:The purpose of this study was to observe the clinical effect of the wart removal decoction combined with interferon in the treatment of dampness-heat diffusing downward type cervical HR-HPV infection with CINⅠ.Methods:Eighty patients with dampness-heat diffusing downward type cervical HR-HPV infection with CINⅠwho met the diagnostic criteria were selected and randomly divided into treatment group and control group,with 40 patients in each group.The control group was treated with recombinant human interferon α-2b gel,the treatment group was treated the same in addition to wart removal decoction for external washing for 3 menstrual cycles.Traditional Chinese medicine(TCM)syndrome score,HR-HPV negative conversion rate,CINⅠ improvement and P16/Ki-67 expression in cervical lesion epithelium were observed before and after treatment.Results:TCM syndrome score after treatment was significantly lower than that before treatment in the two groups(P<0.01).TCM syndrome score,HR-HPV negative conversion rate,CINⅠ improvement effect rate,and negative conversion rate of P16/Ki-67 positive expression in the treatment group was superior over the control group(P<0.01,P<0.05).Conclusion:The clinical effect of wart removal decoction combined with interferon in the treatment of patients with damp-heat type cervical HR-HPV infection with CINⅠ is remarkable.The therapeutic regimen can significantly improve the clinical manifestations of TCM in patients,promote the conversion of HR-HPV to negative direction,reverse the progression of CINⅠ,and reduce the positive expression of P16/Ki-67 in cervical epithelial cells.Its efficacy is superior to that of only interferon group,with clinical significance.
作者
董书含
刘雪平
刘丽
袁孟珂
DONG Shuhan;LIU Xueping;LIU Li;YUAN Mengke(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Hebei University of Chinese Medicine,Shijiazhuang 050091,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中医药学报》
CAS
2024年第6期62-68,共7页
Acta Chinese Medicine and Pharmacology
基金
教育部“春晖计划”合作科研项目(HLJ2019032)。
