摘要
目的:观察补肾健脾安胎汤联合地屈孕酮治疗肾虚型高龄先兆流产的临床疗效及对血清总三碘甲状腺激素(TT3)、雌二醇(E2)、孕酮(P)水平的影响。方法:选取肾虚型高龄先兆流产患者60例,按随机数字表法分为观察组与对照组各30例。2组孕妇均采用地屈孕酮治疗,观察组加用补肾健脾安胎汤治疗,对照组加用维生素E胶囊治疗。比较2组临床疗效、中医证候评分、相关性激素指标、子宫动脉血流参数[搏动指数(PI)、阻力指数(RI)]、继续妊娠率及症状缓解时间。结果:观察组总有效率为93.33%,对照组为70.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组出血、小腹坠痛、腰酸软、夜尿频多、头晕耳鸣等中医证候评分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组血清E_(2)、P、TT3水平均较治疗前升高(P<0.05);且观察组E2、P均高于对照组(P<0.05);而2组TT3水平比较,差异无统计学意义(P>0.05)。治疗后,2组PI、RI水平均较治疗前下降(P<0.05),且观察组PI、RI水平均低于对照组(P<0.05)。随访6个月,观察组继续妊娠率为90.00%,对照组为66.67%,2组比较,差异有统计学意义(P<0.05)。观察组先兆流产症状缓解时间短于对照组,差异有统计学意义(P<0.05)。结论:补肾健脾安胎汤联合地屈孕酮治疗高龄先兆流产,可上调血清P、E2水平,提高临床疗效,改善患者临床症状,加速症状缓解,提高继续妊娠率。
Objective:To observe the clinical effect of Bushen Jianpi Antai Decoction combined with Dydrogesterone in the treatment of elderly patients with kidney deficiency syndrome threatened abortion and the influence of serum total triiodothyroid hormone(TT3),estradiol(E2)and progesterone(P)levels.Methods:A total of 60 cases of patients with elderly threatened abortion of kidney deficiency type were selected and divided into the observation group and the control group according to the random number table method,with 30 cases in each group.Both groups were treated with Dydrogesterone;the observation group was additionally treated with Bushen Jianpi Antai Decoction,and the control group was additionally treated with Vitamin E Capsules.The clinical effects,traditional Chinese medicine(TCM)syndrome scores,related indexes of sex hormones,uterine artery blood flow parameters[pulsatility index(PI)and resistance index(RI)],ongoing pregnancy rates and relief time of symptoms were compared between the two groups.Results:The total effective rate was 93.33%in the observation group and 70.00%in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores including bleeding,bearing-down pain in lower abdomen,soreness and weakness of waist,frequent nocturia,and dizziness and tinnitus in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of E_(2),P and TT3 in serum in the two groups were increased when compared with those before treatment(P<0.05);the levels of E2 and P in the observation group were higher than those in the control group(P<0.05),but there was no significant difference being found in the comparison of TT3 levels between the two groups(P>0.05).After treatment,the levels of PI and RI in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of PI and RI in the observation group were lower than those
作者
胡丽芳
宋继超
HU Lifang;SONG Jichao(Department of Gynecology,Xinchang People's Hospital,Xinchang Zhejiang 312500,China)
出处
《新中医》
CAS
2024年第8期106-110,共5页
New Chinese Medicine
关键词
先兆流产
补肾健脾安胎汤
地屈孕酮
总三碘甲状腺激素
雌二醇
继续妊娠率
Threatened abortion
Bushen Jianpi Antai Decoction
Dydrogesterone
Total triiodothyronine
Estradiol
Continuing pregnancy rate
