摘要
目的了解天津市猴痘疫情的流行特征与病例临床表现,为猴痘防控提供科学依据。方法本研究收集病例人口基本信息、流行病学史、发病就诊经过与临床特征等方面信息进行统计学分析。结果2023年6月至2024年1月天津市累计报告病例44例。病例均为男性,年龄中位数为37岁,其中34.09%为已婚状态,36.36%有人类免疫缺陷病毒(HIV)感染史。44例病例均通过同性性接触传播,平均潜伏期为8 d,无其他可疑暴露史。一半以上病例在确诊前有≥2次的就诊经历,首诊医院类型是诊断延时的影响因素(P=0.049)。在全病程中,病例身体均出现不同部位皮疹,其中生殖器皮疹比例最高为56.82%;多数病例出现发热、皮疹部位瘙痒疼痛。无HIV感染组病例生殖器皮疹与发热的比例明显高于有HIV感染组[P=0.010(生殖器皮疹),P=0.038(发热)]。结论天津市猴痘疫情在男男性行为人群(MSM)中传播,健康宣传教育应重点在MSM中进行,同时考虑到该人群中部分也与异性发生性接触,健康宣教也应兼顾其他人群;加强医疗机构培训,提高其识别、诊断猴痘的敏感性。
Objective To understand the epidemiological characteristics and clinical manifestations of mpox cases in Tianjin,so as to provide scientific basis for the prevention and control of mpox.Methods The demographic information,epidemiological history,disease onset and treatment information as well as clinical features of the patients were collected in the study for statistical analysis.Results A total of 44 case were reported in Tianjin from June 2023 to January 2024.All cases were male patients with the median age of 37 years old.Among the patients,34.09%were married and 36.36%had a history of human immunodeficiency virus(HIV)infection.All 44 cases were transmitted through homosexual contacts.The average incubation period was 8 days.There was no other suspected exposure history.More than half of the cases had 2 or more visits to the hospital before diagnosis.The type of the first hospital was the influencing factor of the timely diagnosis(P=0.049).In the whole course of disease,all cases had rashes in different parts of the body,and the proportion of genital rashes was the highest(56.82%).Most cases had fever,pruritus and pain at the sites of rashes.The ratio of genital rash and fever in the non-HIV infected group was significantly higher than those in HIV infected patients group(P=0.010 for genital rash,P=0.038 for fever).Conclusions The mpox spreaded among men who have sex with men(MSM)in Tianjin.Health promotion and education should focus on MSM.Considering the possibility that people in this group may have heterosexual behaviors with females,health education should be also applied for other groups of people.The training in medical institutions should be improved to increase vigilance for recognition and diagnose of mpox.
作者
卢婷婷
吕杰
刘怡芳
褚珏
武子明
李琳
Lu Tingting;Lyu Jie;Liu Yifang;Chu Jue;Wu Ziming;Li Lin(Institute for Infectious Disease Prevention and Control,Tianjin Center for Disease Control and Prevention,Tianjin 300011,China;Department of Infectious Disease Prevention and Control,Nankai District Center for Disease Control and Prevetion,Tianjin 300011,China)
出处
《国际病毒学杂志》
北大核心
2024年第2期104-108,共5页
International Journal of Virology
基金
天津市医学重点学科(TJYXZDXK-050A)
国家疾病预防控制局公共卫生人才培养支持项目。
关键词
猴痘
流行特征
临床特征
男男性行为者
Mpox
Epidemiological characteristics
Clinical feature
Men who have sex with men
