摘要
目的探讨孕期增长体质量、脂代谢指标与妊娠糖尿病(GDM)患者不良妊娠结局的关系。方法选取2020年1月至2022年12月该院收治的120例GDM患者作为观察组,另选取同期在本院体检的健康孕妇795例作为对照组,再按照妊娠结局将GDM患者分为正常妊娠结局组及不良妊娠结局组。比较观察组和对照组孕期增长体质量、孕早、晚期脂代谢指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、不良妊娠结局发生情况。比较不良妊娠结局组与正常妊娠结局组孕前体质量指数(BMI)、孕期增长体质量情况、孕早、晚期脂代谢指标。采用多因素Logistic回归分析GDM患者发生不良妊娠结局的危险因素。结果观察组孕期增长体质量高于对照组(P<0.05)。观察组孕晚期的TG、TC、LDL-C水平高于正常妊娠结局组,HDL-C水平低于正常妊娠结局组,差异均有统计学意义(P<0.05)。观察组不良妊娠结局总发生率高于对照组(P<0.05)。不良妊娠结局组有37例患者,正常妊娠结局组有83例患者。不良妊娠结局组与正常妊娠结局组孕前BMI和孕期增长体质量过少的患者比例比较,差异均无统计学意义(P>0.05)。不良妊娠结局组孕期增长体质量适宜的患者比例低于正常妊娠结局组,孕期增长体质量过多的患者比例高于正常妊娠结局组,差异均有统计学意义(P<0.05)。不良妊娠结局组孕晚期的TG、TC、LDL-C水平高于正常妊娠结局组,HDL-C水平低于正常妊娠结局组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,孕期增长体质量过多及孕晚期TG≥3.64 mmol/L、TC≥7.95 mmol/L、HDL-C≤1.65 mmol/L、LDL-C≥5.17 mmol/L是GDM患者发生不良妊娠结局的独立危险因素(P<0.05)。结论GDM患者存在孕期增长体质量过多现象,孕期增长体质量过多及孕晚期TG≥3.64 mmol/L、TC≥7.95 mmol/L、HDL-C≤1.65 mmol/L、LDL-C≥5.1
Objective To investigate the relationship between gestational weight gain,lipid metabolism indexes and adverse pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 120 GDM patients admitted to the hospital from January 2020 to December 2022 were selected as the observation group,and 795 healthy pregnant women underwent physical examination in the hospital during the same period were selected as the control group.According to the pregnancy outcome,the GDM patients were divided into normal pregnancy outcome group and adverse pregnancy outcome group.The gestational weight gain,lipid metabolism indexes[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and total adverse pregnancy outcomes were compared between the observation group and the control group.pre-pregnancy body mass index(BMI),gestational weight gain and lipid metabolism indexes in early and late pregnancy were compared between the adverse pregnancy outcome group and the normal pregnancy outcome group.Multivariate Logistic regression was used to analyze the risk factors of adverse pregnancy outcomes in GDM patients.Results The gestational weight gain of the observation group was higher than that of the control group(P<0.05).The levels of TG,TC and LDL-C in the observation group were higher than those in the control group,and the levels of HDL-C in the observation group were lower than those in the control group,with statistical significance(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was higher than that in the control group(P<0.05).There were 37 patients in the adverse pregnancy outcome group and 83 patients in the normal pregnancy outcome group.There was no significant difference in the proportion of patients with low pre-pregnancy BMI and increased gestational weight gain between the adverse pregnancy outcome group and the normal pregnancy outcome group(P>0.05).The proportion of patients with appropriate gestat
作者
叶青燕
吴凯
练华珍
YE Qingyan;WU Kai;LIAN Huazhen(Department of Obstetrics and Gynecology,the First Hospital of Nanping,Fujian Medical University,Nanping,Fujian 353000,China)
出处
《检验医学与临床》
CAS
2024年第11期1622-1626,共5页
Laboratory Medicine and Clinic
关键词
妊娠糖尿病
孕期增长体质量
脂代谢指标
不良妊娠结局
危险因素
gestational diabetes mellitus
gestational weight gain
lipid metabolism index
adverse pregnancy outcome
risk factor
